Table 1.
Relevant published studies on survival following ablation of colorectal liver metastases initially ineligible for resection alone within 10 years.
| Author/Year | Type of Study | Intervention | Approach | Number of Patients/Lesions | Mean/Median Tumor Size (cm) | Mean/Median Tumor Number | Median Follow-Up Period in Months | 3-y OS (%) | 4-y OS (%) | 5-y OS (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| Tinguely/2020 [132] | Retrospective | MWA | Percutaneous or surgical | 82 | 3 * | n/a | 25.2 | 69.1 | n/a | n/a |
| Thai Doan/2020 [133] | Retrospective | RFA | Percutaneous | 61 | n/a | 2.7 | 24 | 44.5 | n/a | 38.2 |
| Cornelis/2020 [70] | Retrospective | IRE | Percutaneous | 25 | n/a | n/a | 25 | 26.8 | n/a | n/a |
| Schicho/2019 [62] | Retrospective | IRE | Percutaneous | 24 | 2 | 2 | 26.5 | 25 | n/a | 8.3 |
| Ruers/2017 [38] | Prospective | RFA ± resection | Percutaneous or surgical | 60 † | 4 * | 4 | 116.4 | 56.9 | n/a | 43.1 |
| Engstrand/2014 [134] | Retrospective | MWA | Surgical | 20 | 2.7 | 9 | 25 | n/a | 41 | n/a |
| Evrard/2012 [135] | Prospective | RFA ± resection | Surgical | 52 | 1 | 5 | 34.8 | n/a | n/a | 43 |
| Kim/ 2011 [129] | Retrospective | RFA | Percutaneous or surgical | 177 | 2.1 | 1.6 | 41.2 | n/a | n/a | 51 |
| Van Tilborg/2011 [136] | Retrospective | RFA | Percutaneous or surgical | 100 | 2.4 | 1.9 | 29 | 77 | n/a | 36 |
Abbreviations—IRE: irreversible electroporation; MWA: microwave ablation; n/a: not available; OS: overall survival; RFA: radiofrequency ablation. *: Maximal diameter. †: combined modality arm (systemic treatment plus aggressive local treatment by radiofrequency ablation ± resection).