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Decreased protein stability of CAST in aged livers. (A) CAST expression in human livers at different ages before the commencement of ischemia (n = 6). (B) Alterations of CAST expression in young and aged mouse hepatocytes in the presence of 35 μM CHX (n = 5). (C) Effects of 10 μM ALLM (calpain inhibitor) and 50 μM MG132 (proteasome inhibitor) on CAST expression in aged hepatocytes during I/R (n = 3). * p < 0.05 and ** p < 0.01.
