Figure 2.

Platelet BMP-4 mediates re-endothelialization, endothelial cell proliferation and migration. (A) En-face staining of the denuded carotid with Evans blue after wire injury in BMP4^Plt−/− mice (n = 6) and control (n = 5). (B) Proliferation assay of endothelial cells stimulated with platelets (2 × 10⁷ per well) isolated from BMP4^Plt−/− mice or control littermates. n = 5 per group. (C) Wound healing of MCECs treated with platelets (1 × 10⁸ per well) isolated from BMP4^Plt−/− mice (n = 6 independent experiments) or control littermates (n = 5 independent experiments). * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.