Figure 3.

Platelet BMP-4 mediates leukocyte rolling and adhesion to the vessel wall. (A) Intravital microscopy of the mesenteric venules of control (BMP4^Plt+/+) or BMP4^Plt−/− mice upon stimulation with TNFα (10 ng/g body weight). n = 6 per group. (B,C) mRNA expression of ICAM-1 and VCAM-1 in carotid arteries from control littermates or BMP4^Plt−/−/LDLr^−/− mice after guide wire injury. n = 8 per group. (D,E) Protein expression of the adhesion molecules ICAM-1 and VCAM-1 in carotid arteries from control littermates or BMP4^Plt−/−/LDLr^−/− mice after guide wire injury. n = 3 independent experiments; * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001. n.s., not significant.