Table 2.
Dendritic cell, monocyte and basic peripheral blood lymphocyte subset counts, as well as the frequencies of these cell subsets expressing the TLR2 antigen in the study and control group.
| Parameter [%] | Ovarian Cancer Group (n = 50) | Healthy Control Group (n = 30) | t/Z Value | p-Value |
|---|---|---|---|---|
| Mean ± SD/Median (Range) | ||||
| White blood cells (103/mm3) | 8.2 ± 1.7 | 7.3 ± 0.65 | 2.8 | 0.0057 |
| Neutrophils (103/mm3) | 4.9 ± 1.5 | 4.26 ± 0.9 | 2.1 | 0.037 |
| Monocytes (103/mm3) | 0.51 ± 0.17 | 0.44 ± 0.12 | 1.8 | 0.069 |
| Lymphocytes (103/mm3) | 2.3 ± 0.7 | 2.5 ± 0.5 | −1.5 | 0.13 |
| Myeloid dendritic cells BDCA1+ CD19− | 0.26 (0.04–0.72) | 0.42 (0.12–0.69) | −2.5 | 0.012 |
| Plasmacytoid dendritic cells BDCA2+ CD123+ | 0.33 (0.14–0.99) | 0.26 (0.07–0.58) | 2.4 | 0.016 |
| Myeloid dendritic cells BDCA1+ CD19−/Plasmacytoid dendritic cells BDCA2+ CD123+ ratio | 0.74 (0.11–4.4) | 1.6 (0.37–5.3) | −3.5 | 0.0004 |
| Classical monocytes CD14+ CD16− | 87.0 ± 5.4 | 91.1 ± 3.3 | −4.3 | <0.0001 |
| Non-classical monocytes CD14+ CD16+ | 8.45 (2.3–20.5) | 4.6 (2.2–13.5) | 3.8 | 0.0001 |
| T lymphocytes CD3+ | 72.9 (62.0–79.9) | 71.5 (63.0–78.2) | 0.85 | 0.39 |
| B lymphocytes CD19+ | 11.0 (6.7–17.1) | 11.8 (6.5–17.0) | −0.97 | 0.33 |
| NK cells CD3− CD16+ CD56+ | 11.8 ± 4.3 | 14.6 ± 3.3 | −3.1 | 0.0024 |
| NKT-like cells CD3+ CD16+ CD56+ | 2.2 (0.2–10.1) | 3.3 (1.2–5.0) | −1.6 | 0.099 |
| T lymphocytes CD3+ CD4+ | 40.7 ± 5.7 | 40.4 ± 3.3 | 0.25 | 0.8 |
| T lymphocytes CD3+ CD8+ | 29.5 ± 5.5 | 30.4 ± 3.8 | −0.8 | 0.4 |
| T lymphocytes ratio CD3+ CD4+/T CD3+ CD8+ | 1.35 (0.73–3.0) | 1.3 (0.96–1.96) | 0.48 | 0.63 |
| Myeloid dendritic cells BDCA1+ CD19− TLR2+ | 17.1 (1.6–52.0) | 4.1 (1.25–10.0) | −2.5 | 0.012 |
| Plasmacytoid dendritic cells BDCA2+ CD123+ TLR2+ | 10.6 (2.5–43.9) | 5.4 (1.0–16.5) | 3.7 | 0.0002 |
| Classical monocytes CD14+ CD16− TLR2+ | 5.4 (2.3–30.3) | 4.0 (1.95–16.0) | 2.3 | 0.021 |
| Non-classical monocytes CD14+ CD16+ TLR2+ | 10.0 (1.5–35.8) | 4.7 (0.9–18.0) | 3.2 | 0.0014 |
| T lymphocytes CD4+ TLR2+ | 2.7 (0.3–24.1) | 0.82 (0.08–3.5) | 4.9 | <0.0001 |
| T lymphocytes CD8+ TLR2+ | 2.2 (0.3–24.0) | 1.1 (0.19–6.0) | 2.5 | 0.013 |
| B lymphocytes CD19+ TLR2+ | 3.8 (0.6–30.0) | 2.5 (0.17–6.9) | 2.5 | 0.012 |
| TLR2 concentration in serum (ng/mL) | 11.5 (2.5–74.9) | 3.6 (0.34–20.9) | 4.4 | <0.0001 |