Table 2.
Hazard ratios for each of the assessed outcome considering the entire cohort and separately males/females, along with the p for trend among quartiles for each outcome and the relative p for interaction for the sex-based subgroup analysis
| MODEL | Label | Overall | Male | Female | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HRCI |
ProbChi Sq |
p for trend | HRCI |
ProbChi Sq |
p for trend | HRCI |
ProbChi Sq |
p for trend | p for interaction | ||
| Primary Composite Outcome | vikt_STD_Q2 | 1.08 (1.03–1.12) | 0.0012 | < .0001 | 1.11 (1.05–1.18) | 0.0005 | < .0001 | 1.03 (0.97–1.11) | 0.3152 | < .0001 | 0.539 |
| vikt_STD_Q3 | 1.18 (1.13–1.24) | < .0001 | 1.20 (1.13–1.28) | < .0001 | 1.16 (1.08–1.24) | < .0001 | |||||
| vikt_STD_Q4 | 1.45 (1.39–1.52) | < .0001 | 1.46 (1.37–1.55) | < .0001 | 1.46 (1.36–1.56) | < .0001 | |||||
| Expanded Composite Outcome | vikt_STD_Q2 | 1.06 (1.02–1.11) | 0.0057 | < .0001 | 1.08 (1.02–1.15) | 0.0050 | < .0001 | 1.03 (0.97–1.10) | 0.3296 | < .0001 | 0.823 |
| vikt_STD_Q3 | 1.16 (1.11–1.21) | < .0001 | 1.16 (1.10–1.23) | < .0001 | 1.15 (1.08–1.23) | < .0001 | |||||
| vikt_STD_Q4 | 1.41 (1.35–1.47) | < .0001 | 1.39 (1.31–1.48) | < .0001 | 1.43 (1.34–1.53) | < .0001 | |||||
| All cause mortality | vikt_STD_Q2 | 1.10 (1.05–1.16) | 0.0003 | < .0001 | 1.12 (1.05–1.21) | 0.0015 | < .0001 | 1.08 (1.00–1.17) | 0.0393 | < .0001 | 0.527 |
| vikt_STD_Q3 | 1.27 (1.21–1.34) | < .0001 | 1.31 (1.21–1.41) | < .0001 | 1.23 (1.14–1.33) | < .0001 | |||||
| vikt_STD_Q4 | 1.68 (1.59–1.77) | < .0001 | 1.72 (1.60–1.85) | < .0001 | 1.63 (1.51–1.76) | < .0001 | |||||
| MI | vikt_STD_Q2 | 0.99 (0.90–1.08) | 0.7542 | 0.06 | 1.03 (0.92–1.16) | 0.5893 | 0.81 | 0.91 (0.79–1.06) | 0.2412 | 0.01 | 0.085 |
| vikt_STD_Q3 | 1.04 (0.65–1.15) | 0.3902 | 1.04 (0.92–1.18) | 0.5205 | 1.04 (0.89–1.22) | 0.5924 | |||||
| vikt_STD_Q4 | 1.12 (1.02–1.24) | 0.0225 | 1.07 (0.94–1.22) | 0.3382 | 1.23 (1.05–1.44) | 0.0109 | |||||
| Stroke | vikt_STD_Q2 | 1.04 (0.95–1.14) | 0.3497 | 0.0002 | 1.11 (0.98–1.25) | 0.0879 | 0.003 | 0.97 (0.85–1.11) | 0.6472 | 0.03 | 0.366 |
| vikt_STD_Q3 | 1.07 (0.98–1.18) | 0.1344 | 1.09 (0.96–1.23) | 0.2022 | 1.06 (0.93–1.22) | 0.3750 | |||||
| vikt_STD_Q4 | 1.24 (1.13–1.37) | < .0001 | 1.28 (1.12–1.47) | 0.0002 | 1.20 (1.04–1.38) | 0.0151 | |||||
| PCI | vikt_STD_Q2 | 0.97 (0.87–1.07) | 0.5287 | 0.86 | 0.98 (0.87–1.11) | 0.7819 | 0.69 | 0.92 (0.76–1.12) | 0.4182 | 0.19 | 0.447 |
| vikt_STD_Q3 | 0.97 (0.87–1.08) | 0.5657 | 0.94 (0.81–1.07) | 0.3136 | 1.04 (0.86–1.27) | 0.6750 | |||||
| vikt_STD_Q4 | 1.00 (0.89–1.12) | 0.9597 | 0.94 (0.81–1.08) | 0.3517 | 1.16 (0.95–1.42) | 0.1394 | |||||
| CABG | vikt_STD_Q2 | 0.86 (0.72–1.02) | 0.0858 | 0.23 | 0.84 (0.69–1.03) | 0.0939 | 0.27 | 0.92 (0.64–1.33) | 0.6639 | 0.90 | 0.701 |
| vikt_STD_Q3 | 0.84 (0.70–1.01) | 0.0707 | 0.84 (0.68–1.03) | 0.0892 | 0.86 (0.58–1.29) | 0.4640 | |||||
| vikt_STD_Q4 | 0.90 (0.74–1.09) | 0.2915 | 0.88 (0.71–1.10) | 0.2711 | 0.95 (0.63–1.44) | 0.8197 | |||||
| HF | vikt_STD_Q2 | 1.03 (0.95–1.11) | 0.4831 | < .0001 | 1.07 (0.96–1.19) | 0.2308 | < .0001 | 0.99 (0.89–1.10) | 0.8338 | < .0001 | 0.828 |
| vikt_STD_Q3 | 1.18 (1.09–1.27) | < .0001 | 1.26 (1.13–1.39) | < .0001 | 1.09 (0.98–1.22) | 0.1262 | |||||
| vikt_STD_Q4 | 1.43 (1.32–1.55) | < .0001 | 1.48 (1.32–1.65) | < .0001 | 1.39 (1.24–1.55) | < .0001 | |||||
| PAD | vikt_STD_Q2 | 1.00 (0.86–1.17) | 0.9761 | < .0001 | 1.03 (0.85–1.26) | 0.7363 | 0.002 | 0.95 (0.75–1.21) | 0.6702 | < .0001 | 0.598 |
| vikt_STD_Q3 | 1.15 (0.98–1.34) | 0.0833 | 1.10 (0.90–1.35) | 0.3560 | 1.20 (0.94–1.53) | 0.1342 | |||||
| vikt_STD_Q4 | 1.55 (1.33–1.81) | < .0001 | 1.43 (1.17–1.75) | 0.0006 | 1.69 (1.34–2.14) | < .0001 | |||||
| Lower limb revascularization | vikt_STD_Q2 | 0.92 (0.78–1.09) | 0.3244 | 0.001 | 0.96 (0.77–1.20) | 0.7338 | 0.05 | 0.87 (0.68–1.12) | 0.2895 | 0.04 | 0.801 |
| vikt_STD_Q3 | 1.07 (0.90–1.26) | 0.4522 | 1.13 (0.90–1.41) | 0.3087 | 1.00 (0.77–1.29) | 0.9779 | |||||
| vikt_STD_Q4 | 1.31 (1.10–1.56) | 0.0022 | 1.32 (1.04–1.67) | 0.0230 | 1.30 (1.01–1.67) | 0.0447 | |||||
| Foot Ulcer | vikt_STD_Q2 | 1.02 (0.82–1.27) | 0.8462 | < .0001 | 1.01 (0.75–1.37) | 0.9373 | 0.05 | 1.01 (0.73–1.40) | 0.9364 | 0.001 | 0.239 |
| vikt_STD_Q3 | 1.30 (1.04–1.61) | 0.0194 | 1.25 (0.93–1.69) | 0.1380 | 1.31 (0.95–1.79) | 0.0989 | |||||
| vikt_STD_Q4 | 1.61 (129–2.00) | < .0001 | 1.45 (1.07–1.97) | 0.0171 | 1.73 (1.27–2.36) | 0.0006 | |||||