Table 2.
List of PET tracers (and targets) investigated in animal models of PC.
| Molecular Target | Tracer | Animal Model | Clinical Relevance | Reference |
|---|---|---|---|---|
| Integrin αvβ6 | [68Ga]Ac-CG6 | AsPC-1 MIA PaCa-2 |
Specific affinity to αvβ6 | Ui T, Bioorganic and Medicinal Chemistry, 2020 [66] |
| Integrin αvβ6 | [68Ga]DOTA-SFLAP3 | Capan-2 | Specific affinity to αvβ6 | Muller M, Nuklearmedizin 2019 [67] |
| Integrin α3β1 | [68Ga]NOTA-CK11 | SW1990 | Specific affinity to α3β1 | Li H, Mol Pharm 2020 [68] |
| Neurotensin receptor 1 (NTS1) | [68Ga]DOTA-NT20.3 | AsPC-1 | Differential diagnosis for tumour and not for inflammatory lesion | Prignon A, Mol Pharm 2019 [69] |
| Hepatocarcinomaintestine-pancreas and pancreatitis-associated protein (HIP/PAP) | [18F]FEL | T3M4 | Differentiating tumors from aseptic inflammation | Yao S, Oncotarget 2017 [70] |
| Tissue factor (TF) CD105 |
[64Cu]-NOTA-heterodimer | BxPC-3 (TF/CD105+/+) | Specific affinity to TF and CD105 | Luo H, Clin Cancer Res. 2016 [71] |