Table 2.
Sample description for imputed genotype chip cohorts
| Population | Cohort | N | Age | Percent female | BMI | Apnea-hypopnea index 3% | AHI (percent < 5, 5–15, ≥ 15) | Average desaturation | Average SpO2 | Minimum SpO2 | Percent sleep under 90% SpO2 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| African-American | CFS* | 225 | 35.46 (20.32) | 56.4 | 29.97 (10.09) | 3.99 (10.55) | 55.1, 23.1, 21.8 | 2.90 (1.09) | 94.65 (4.01) | 88.17 (9.60) | 5.20 (16.01) |
| European-American, Australian | ARIC | 631 | 62.74 (5.72) | 49.4 | 29.15 (5.23) | 9.15 (15.02) | 29.3, 37.9, 32.8 | 2.50 (1.73) | 94.32 (2.15) | 85.17 (6.17) | 4.12 (11.76) |
| CFS* | 218 | 37.57 (18.66) | 56.9 | 28.76 (8.11) | 3.4 (10.59) | 57.8, 22.5, 19.7 | 2.30 (1.11) | 94.09 (3.35) | 88.81 (7.80) | 3.26 (12.79) | |
| CHS | 365 | 77.44 (4.65) | 64.9 | 27.10 (4.41) | 10.50 (15.14) | 25.8, 39.2, 35.1 | 2.63 (1.57) | 94.41 (1.91) | 84.87 (5.96) | 3.93 (11.89) | |
| FHS* | 192 | 57.45 (9.68) | 51.0 | 28.87 (5.16) | 7.30 (14.38) | 38.0, 31.8, 30.2 | 2.42 (1.51) | 94.73 (1.80) | 85.76 (5.46) | 2.82 (8.38) | |
| MrOS | 2181 | 76.65 (5.60) | 0.0 | 27.21 (3.75) | 13.00 (18.00) | 18.9, 36.1, 45.0 | 3.54 (1.48) | 93.85 (1.73) | 84.39 (5.88) | 4.40 (9.95) | |
| WASHS | 1508 | 52.29 (13.71) | 40.9 | 31.84 (7.93) | 7.24 (15.37) | 40.1, 31.1, 28.8 | 3.56 (2.00) | 94.56 (2.38) | 84.61 (7.86) | 5.44 (13.82) | |
| Hispanic, Latino-American | HCHS, SOL | 7155 | 46.10 (13.81) | 57.8 | 29.68 (5.86) | 2.00 (6.15) | 69.1, 19.3, 11.6 | N, A | 96.46 (0.95) | 87.06 (6.11) | 0.83 (2.99) |
| Starr | 782 | 52.34 (11.29) | 71.9 | 32.15 (6.78) | 10.35 (17.18) | 31.5, 31.5, 37.1 | N, A | 94.65 (2.09) | 85.78 (7.50) | 2.83 (8.79) |
Eight studies contributed 13,257 individuals with genomic data imputed with a TOPMed Freeze 5b reference panel and objectively measured phenotypes (225 African-Americans, 5095 European-Americans, 7937 Hispanic/Latino-Americans). ARIC, CFS, CHS, FHS, and HCHS/SOL imputed genomic data reflect individuals without available sequencing in TOPMed Freeze 6. The overall sample had a mean age of 53.7 and was 46.9% female. Values are displayed as mean (SD), except for the skewed apnea-hypopnea Index, which is displayed as median (IQR). Sample size N reflects individuals with non-missing AHI and covariate values. *Family cohort