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. 2021 Jul 31;11(8):1131. doi: 10.3390/biom11081131

Figure 3.

Figure 3

Single-domain antibodies (nanobodies and VNARs) BBB permeability due to receptor-mediated transcytosis. Several membrane receptors which are present on the surface of the endothelial cells of the BBB have been proposed to mediate the transcytosis of single-domain antibodies (nanobodies and VNARs) to transport them into the brain parenchyma (alpha(2,3)-sialoglycoprotein receptor (α(2,3)-SGPR); insulin-like growth factor 1 receptor (IGF1R); vascular cell adhesion molecule 1 (VCAM-1); prion proteins (PrPs); transferrin receptor-1 (TfR1)). Image created with BioRender.com (accessed on 17 June 2021).