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Nanobody BBB permeability due to Adsorptive-Mediated Transcytosis. The positive charged surface of single-domain antibodies (nanobodies and VNARs) with basic pI (~9.5) allow them to spontaneously interact with the cell membrane of the endothelial cells of the BBB, mediating their transcytosis into the brain parenchyma. Image created with BioRender.com (accessed on 17 June 2021).
