Table 5.
Hierarchical ORs for CIN3+ for hrHPV genotypes and for different viral load groups [high, intermediate (Inter), and low], ordered by the genotype hierarchy and weighted to the statewide population of women
| HPV type | Viral load (N, %) | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value |
|---|---|---|---|---|---|---|---|
| Any hrHPVa | High (18,541, 0.6) | 77.31 (46.48–128.61) | 9.4E-63 | 4.94 (3.35–7.28) | 8.1E-16 | 2.53 (2.00–3.19) | 6E-15 |
| Inter (13,374, 0.4) | 30.57 (17.87–52.30) | 1.0E-35 | 1.95 (1.28–2.98) | 2.0E-03 | Ref. | ||
| Low (18,558, 0.6) | 15.66 (8.42–29.11) | 3.6E-18 | Ref. | ||||
| Negative (277,954, 84.6) | Ref. | ||||||
| P value (trend) | 2.6E-123 | 3.0E-20 | |||||
| 16 | High (6,171, 1.9) | 55.28 (44.27–69.03) | 5.3E-271 | 5.48 (2.57–11.67) | 1.1E-05 | 3.18 (2.16–4.69) | 5.1E-09 |
| Inter (2,431, 0.7) | 17.36 (11.56–26.08) | 6.1E-43 | 1.72 (0.75–3.94) | 0.20 | Ref. | ||
| Low (2,844, 0.9) | 10.09 (4.70–21.67) | 3.1E-09 | Ref. | ||||
| Negative (316,981, 96.5) | Ref. | ||||||
| P value (trend) | 2.8E-286 | 4.7E-08 | |||||
| 33 | High (564, 0.2) | 20.42 (10.45–39.92) | 1.2E-18 | 4.04 (1.07–15.32) | 0.04 | 0.62 (0.21–1.83) | 0.39 |
| Inter (287, 0.1) | 32.97 (13.56–80.19) | 1.3E-14 | 6.53 (1.53–27.84) | 0.01 | Ref. | ||
| Low (509, 0.2) | 5.05 (1.55–16.46) | 7.2E-03 | Ref. | ||||
| Negative (315,622, 96.1) | Ref. | ||||||
| P value (trend) | 1.6E-31 | 0.04 | |||||
| 31 | High (781, 0.2) | 11.27 (4.76–26.65) | 3.5E-08 | 1.01 (0.39–2.61) | 0.98 | 0.40 (0.16–0.99) | 0.05 |
| Inter (1,807, 0.6) | 28.28 (18.23–43.88) | 3.6E-50 | 2.53 (1.40–4.59) | 2.2E-03 | Ref. | ||
| Low (2,551, 0.8) | 11.16 (6.65–18.72) | 6.7E-20 | Ref. | ||||
| Negative (310,483, 94.5) | Ref. | ||||||
| P value (trend) | 1.2E-65 | 0.14 | |||||
| 18 | High (1,553, 0.5) | 18.07 (11.03–29.61) | 1.5E-30 | 2.05 (0.70–6.02) | 0.19 | 2.69 (0.90–8.09) | 0.08 |
| Inter (675, 0.2) | 6.71 (2.36–19.08) | 3.6E-04 | 0.76 (0.18–3.14) | 0.70 | Ref. | ||
| Low (855, 0.3) | 8.83 (3.17–24.57) | 3.0E-05 | Ref. | ||||
| Negative (307,399, 93.6) | Ref. | ||||||
| P value (trend) | 2.8E-34 | 0.14 | |||||
| 35 | High (330, 0.1) | 19.30 (7.36–50.60) | 1.8E-09 | 2.97 (0.70–12.70) | 0.14 | 1.27 (0.41–3.97) | 0.68 |
| Inter (848, 0.3) | 15.16 (7.43–30.91) | 7.7E-14 | 2.34 (0.64–8.52) | 0.20 | Ref. | ||
| Low (1,032, 0.3) | 6.49 (2.06–20.43) | 1.4E-03 | Ref. | ||||
| Negative (305,189, 92.9) | Ref. | ||||||
| P value (trend) | 2.8E-23 | 0.09 | |||||
| 58 | High (1,483, 0.5) | 18.46 (10.69–31.89) | 1.5E-25 | 10.33 (1.36–78.49) | 0.02 | 7.87 (1.03–60.04) | 0.05 |
| Inter (595, 0.2) | 2.35 (0.32–17.34) | 0.40 | 1.31 (0.08–21.63) | 0.85 | Ref. | ||
| Low (781, 0.2) | 1.79 (0.24–13.15) | 0.57 | Ref. | ||||
| Negative (302,329, 92.1) | Ref. | ||||||
| P value (trend) | 1.8E-23 | 0.01 | |||||
| 45 | High (919, 0.3) | 9.56 (3.94–23.17) | 5.8E-07 | 0.85 (0.22–3.32) | 0.82 | 0.87 (0.22–3.44) | 0.84 |
| Inter (749, 0.2) | 11.03 (3.51–34.68) | 4.0E-05 | 0.98 (0.21–4.62) | 0.98 | Ref. | ||
| Low (928, 0.3) | 11.24 (3.62–34.90) | 2.8E-05 | Ref. | ||||
| Negative (299,734, 91.3) | Ref. | ||||||
| P value (trend) | 1.4E-13 | 0.82 | |||||
| 52 | High (1,391, 0.4) | 27.06 (14.70–49.82) | 3.6E-26 | 9.93 (2.86–34.39) | 3.0E-04 | 3.10 (1.12–8.57) | 0.03 |
| Inter (1,458, 0.4) | 8.73 (3.31–23.01) | 1.2E-05 | 3.20 (0.75–13.70) | 0.12 | Ref. | ||
| Low (1,888, 0.6) | 2.73 (0.82–9.08) | 0.10 | Ref. | ||||
| Negative (294,996, 89.8) | Ref. | ||||||
| P value (trend) | 3.7E-26 | 9.9E-05 | |||||
| 59 | High (2,164, 0.7) | 18.65 (4.91–70.94) | 1.8E-05 | 3.62 (0.50–26.11) | 0.20 | 2.34 (0.39–14.08) | 0.35 |
| Inter (1,129, 0.3) | 7.98 (2.10–30.27) | 2.3E-03 | 1.55 (0.21–11.20) | 0.66 | Ref. | ||
| Low (1,375, 0.4) | 5.15 (1.08–24.64) | 0.04 | Ref. | ||||
| Negative (290,328, 88.4) | Ref. | ||||||
| P value (trend) | 1.7E-06 | 0.20 | |||||
| 51 | High (876, 0.3) | 8.03 (2.36–27.36) | 8.7E-04 | 0.50 (0.07–3.56) | 0.48 | 0.70 (0.15–3.38) | 0.66 |
| Inter (1,466, 0.4) | 11.42 (3.56–36.65) | 4.3E-05 | 0.70 (0.10–4.86) | 0.72 | Ref. | ||
| Low (2,292, 0.7) | 16.21 (3.08–85.18) | 1.0E-03 | Ref. | ||||
| Negative (285,694, 87.0) | Ref. | ||||||
| P value (trend) | 3.5E-10 | 0.55 | |||||
| 39 | High (978, 0.3) | 13.03 (4.72–36.00) | 7.4E-07 | 5.65 (1.07–29.71) | 0.04 | 1.48 (0.25–8.68) | 0.67 |
| Inter (1,008, 0.3) | 8.83 (1.78–43.85) | 7.7E-03 | 3.83 (0.48–30.33) | 0.20 | Ref. | ||
| Low (2,122, 0.6) | 2.31 (0.53–10.09) | 0.27 | Ref. | ||||
| Negative (281,587, 85.7) | Ref. | ||||||
| P value (trend) | 9.6E-08 | 0.03 | |||||
| 56 | High (750, 0.2) | 7.18 (1.62–31.72) | 9.3E-03 | ||||
| Inter (446, 0.1) | |||||||
| Low (975, 0.3) | |||||||
| Negative (279,416, 85.1) | Ref. | ||||||
| P value (trend) | 0.10 | ||||||
| 68 | High (591, 0.2) | 4.21 (0.55–32.39) | 1.7E-01 | ||||
| Inter (469, 0.1) | |||||||
| Low (402, 0.1) | |||||||
| Negative (277,953, 84.6) | Ref. | ||||||
| P value (trend) | 0.39 |
NOTE: Multiple HPV infections with types ranked higher in the hierarchy are excluded. Separate analyses are shown with low and intermediate viral loads as the reference category.
a
Highest ranked hrHPV type per woman.