TABLE 1.
Tumorigenic properties of PA-1 cells
| Cell line | Growth in nude mice | Latent period (wks) |
|---|---|---|
| Clone 1-neo | 0/3a | >24 |
| Clone 1–AP-2 | 2/5b | 22, 26 |
| Clone 1–AP-2 | 5/6a | 16 |
| Clone 1–GAL4–AP-2 | 5/7a | 8–20 |
| Clone 1–GAL4–VP16 | 2/5b | 4, 6 |
| 9113 | 4/4 | 6 |
| 9113-zeo-PC4c | 0/2a | >32 |
a
Number of cell lines developed from independently picked G418r colonies that formed tumors in nude mice/total number of cell lines tested. G418r colony-derived cell lines were shown to express the transgenes by reverse transcription-PCR.
b
Pool of transfected G418r colonies: number of mice bearing tumors/number of mice injected with cells.
c
Cell lines 9113-zeo-PC4-1 and 9113-zeo-PC4-2. Note that neither of these 9113-zeo-PC4 clones expressing the PC4 cDNA could form tumors in nude mice.