Table 3.
OVA1 Performance When CA125 Is Low-Risk * by Race | ||||||||
---|---|---|---|---|---|---|---|---|
Menopausal Status | N | Sensitivity (%, n/N) | Specificity (%, n/N) | PPV (%, n/N) | NPV (%, n/N) | LR+ | LR− | |
White/Caucasian | All | 1492 | 64.62% | 67.90% | 8.40% | 97.68% | 2.01 | 0.52 |
42/65 | 969/1427 | 42/500 | 969/992 | |||||
Pre | 848 | 54.55% | 75.18% | 5.53% | 98.42% | 2.20 | 0.60 | |
12/22 | 621/826 | 12/217 | 621/631 | |||||
Post | 644 | 69.77% | 57.90% | 10.60% | 96.40% | 1.66 | 0.52 | |
30/43 | 348/601 | 30/283 | 348/361 | |||||
Black/African American | All | 283 | 41.67% | 79.32% | 8.33% | 96.79% | 2.02 | 0.74 |
5/12 | 211/266 | 5/60 | 211/218 | |||||
Pre | 195 | 37.50% | 82.07% | 8.33% | 96.79% | 2.09 | 0.76 | |
3/8 | 151/184 | 3/36 | 151/156 | |||||
Post | 88 | 50.00% | 73.17% | 8.33% | 96.77% | 1.86 | 0.68 | |
2/4 | 60/82 | 2/24 | 60/62 |
PPV, positive predictive value; NPV, negative predictive value; LR+, positive likelihood ratio; LR−, negative likelihood ratio. Cancer prevalence is 4.5% (104/2305). * Low-risk CA125, 67 U/mL for premenopausal subjects; 35 U/mL for postmenopausal or unknown subjects.