Table 2.

Chemotherapy Parameters. Names, units, descriptions, values, and sources of chemotherapy-related parameters used in the model.

Parameter	Unit	Description	Value	Source
f	none	Initial fraction of cells in vulnerable phase of the cell cycle	0.5	[84]
a	day	Cell cycle time	0.6667	[84]
T	day	Duration of drug exposure
$\tau$	day		min($T,fa$)	[84]
${\beta }_1$	mg/L${}^{-1}$	methotrexate efficacy coefficient	2.4780	[84]
${\beta }_2$	mg/L${}^{-1}$	doxorubicin efficacy coefficient	1.8328	[84]
${\beta }_3$	mg/L${}^{-1}$	cisplatin efficacy coefficient	0.1467	[84]
$K_C$	day${}^{-1}$	Rate of chemo-induced tumor death	0.9	[89,102]
$K_{M_N}$	day${}^{-1}$	Rate of chemo-induced death of naive macrophages	0.6	[102]
$K_M$	day${}^{-1}$	Rate of chemo-induced death of macrophages	0.6	[102]
$K_{T_N}$	day${}^{-1}$	Rate of chemo-induced death of naive T-cells	0.6	[102]
$K_{T_h}$	day${}^{-1}$	Rate of chemo-induced death of helper T-cells	0.6	[102]
$K_{T_r}$	day${}^{-1}$	Rate of chemo-induced death of regulatory T-cells	0.6	[102]
$K_{T_c}$	day${}^{-1}$	Rate of chemo-induced death of cytotoxic cells	0.6	[102]
$K_{D_N}$	day${}^{-1}$	Rate of chemo-induced death of naive dendritic cells	0.6	[102]
$K_D$	day${}^{-1}$	Rate of chemo-induced death of dendritic cells	0.6	[102]
${\delta }_{C{T}_c{A}_3}$	none	Effect of cisplatin to promote cancer killing ability of cytotoxic cells	1	Assumed
${\alpha }_{NCA}$	none	Fraction of chemo-induced dying tumor cells that become necrotic cells	0.8	Assumed
${\delta }_{A_1}$	day${}^{-1}$	Decay rate of methotrexate	1.4466	[106]
${\delta }_{A_2}$	day${}^{-1}$	Decay rate of doxorubicin	8.3178	[104]
${\delta }_{A_3}$	day${}^{-1}$	Decay rate of cisplatin	39.9253	[105]