Figure 2.

K6-Lol and K6-NH2 kill HRS and OvCa cells, and are equally active in doxorubicin and cisplatin resistant cells. Cytotoxicity assay. Tumor cells were exposed to increasing concentrations of peptaibols. (A) After 24 h cell viability was evaluated with MTT assay in A2780 and A2780cis, and MTS assay in KM-H2, KM-H2dx, HDLM-2 and HDLM-2dx. Results are mean and SD of three independent experiments. (B) Fold resistance, calculated as the ratio of the IC₅₀ of drug-resistant cells to that of their corresponding parental cell lines. * p < 0.05 vs. doxorubicin and ° p < 0.05 vs. cisplatin. Student’s t test. Doxo, doxorubicin; CDDP, cisplatin.