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. 2021 Jul 30;11(8):1123. doi: 10.3390/biom11081123

Table 2.

Associations of Radiographic Volumes with Cerebrospinal Fluid Cytokine Levels in Intraventricular Hemorrhage Patients by Days Post Hemorrhage Onset.

Days Post Hemorrhage Onset
1–2 (N = 19, 16) a 3–4 (N = 21, 17) 5–6 (N = 17, 14) 7–8 (N = 16, 13) 9–10 (N = 8, 6)
Cytokine Radiographic Variables b Corr c P d Corr p Corr p Corr p Corr p
IL-1alpha ICH Volume (mL) 0.34 0.15 0.34 0.13 0.20 0.44 0.15 0.58 −0.25 0.55
(pg/mL) IVH Volume (mL) −0.25 0.30 0.23 0.32 −0.18 0.50 0.22 0.41 0.08 0.85
PHE Volume (mL) 0.44 0.06 0.38 0.09 0.27 0.30 0.30 0.25 −0.25 0.55
Relative PHE Volume (%) 0.11 0.69 0.08 0.76 −0.23 0.43 0.62 0.02 0.13 0.80
Total Volume e (mL) 0.07 0.77 0.50 0.02 −0.04 0.88 0.10 0.71 −0.41 0.31
IL-1beta ICH Volume (mL) 0.51 0.03 0.09 0.68 0.24 0.35 0.18 0.50 −0.18 0.67
(pg/mL) IVH Volume (mL) 0.10 0.68 0.44 0.049 0.09 0.74 0.22 0.42 −0.07 0.87
PHE Volume (mL) 0.43 0.07 0.03 0.90 0.24 0.34 0.32 0.22 0.04 0.93
Relative PHE Volume (%) −0.35 0.19 −0.20 0.43 −0.16 0.58 0.60 0.03 0.60 0.21
Total Volume (mL) 0.60 0.006 0.34 0.14 0.25 0.34 0.17 0.52 −0.48 0.23
IL-10 ICH Volume (mL) 0.51 0.03 −0.18 0.43 −0.20 0.45 0.07 0.79 −0.25 0.56
(pg/mL) IVH Volume (mL) 0.06 0.80 0.48 0.03 0.63 0.007 0.39 0.14 −0.17 0.69
PHE Volume (mL) 0.48 0.04 −0.29 0.19 −0.11 0.67 0.21 0.43 −0.02 0.97
Relative PHE Volume (%) −0.18 0.52 −0.34 0.19 0.33 0.25 0.44 0.13 0.94 0.005
Total Volume (mL) 0.64 0.003 0.41 0.06 0.34 0.18 0.20 0.47 −0.61 0.11
TNF-alpha ICH Volume (mL) 0.42 0.08 −0.01 0.95 −0.06 0.83 −0.48 0.06 −0.50 0.21
(pg/mL) IVH Volume (mL) 0.22 0.37 0.26 0.26 0.08 0.77 0.25 0.35 0.25 0.55
PHE Volume (mL) 0.28 0.25 −0.08 0.73 −0.14 0.58 −0.44 0.09 −0.50 0.21
Relative PHE Volume (%) −0.50 0.05 −0.10 0.70 −0.40 0.16 0.13 0.67 NA NA
Total Volume (mL) 0.71 0.001 0.27 0.23 0.03 0.92 −0.24 0.38 −0.25 0.55
IL6 ICH Volume (mL) 0.57 0.01 0.01 0.95 −0.09 0.74 0.24 0.37 0.14 0.73
(pg/mL × 103) IVH Volume (mL) 0.00 1.00 0.49 0.03 0.54 0.03 0.27 0.31 −0.52 0.18
PHE Volume (mL) 0.48 0.04 −0.03 0.88 0.04 0.88 0.38 0.14 0.36 0.38
Relative PHE Volume (%) −0.24 0.36 −0.13 0.63 0.35 0.21 0.64 0.02 0.94 0.005
Total Volume (mL) 0.55 0.01 0.32 0.16 0.30 0.25 0.29 0.28 −0.40 0.32
IL8 ICH Volume (mL) 0.39 0.10 0.04 0.87 −0.16 0.53 −0.16 0.55 −0.25 0.55
(pg/mL × 103) IVH Volume (mL) 0.14 0.57 0.49 0.03 0.56 0.02 0.65 0.007 −0.02 0.96
PHE Volume (mL) 0.35 0.14 −0.02 0.94 −0.09 0.73 0.00 1.00 −0.04 0.93
Relative PHE Volume (%) −0.12 0.65 −0.12 0.66 0.20 0.48 0.60 0.03 0.71 0.11
Total Volume (mL) 0.52 0.02 0.29 0.20 0.22 0.39 0.14 0.59 −0.43 0.29
CCL2 ICH Volume (mL) 0.51 0.03 −0.07 0.76 −0.11 0.67 −0.05 0.85 −0.11 0.80
(pg/mL × 103) IVH Volume (mL) −0.13 0.61 0.43 0.05 0.27 0.29 0.73 0.001 0.07 0.87
PHE Volume (mL) 0.53 0.02 −0.17 0.46 −0.10 0.69 −0.01 0.97 −0.23 0.59
Relative PHE Volume (%) −0.12 0.66 −0.12 0.66 −0.01 0.97 0.22 0.47 −0.09 0.87
Total Volume (mL) 0.56 0.01 0.13 0.59 −0.14 0.59 0.32 0.22 0.36 0.39

a (N = x, y), where x is number of patients at this time point and y is number of patients for Relative PHE volume, where ICH Volume > 0. b Measurements at T0 (Radiographic Volumes). c Spearman Correlation. d p-values are bold if p < 0.05. e Total Volume = ICH Volume + IVH Volume. Abbreviations: ICH, intracerebral hemorrhage; IVH, intraventricular hemorrhage; PHE, perihematomal edema; GCS, Glasgow Coma Scale. p-value: Inline graphic p < 0.005 Inline graphic p < 0.05 Inline graphic 0.05 ≤ p ≤ 0.10.