Skip to main content
. 2021 Aug 18;11(8):1234. doi: 10.3390/biom11081234

Figure 1.

Figure 1

Hyaluronan/CD44 interactions involved in T lymphocyte rolling for recruitment to damaged tissue. Recruitment of leukocytes to areas of inflammation consists of four steps: (1) Rolling, (2) Adhesion, (3) Diapedesis, and (4) Migration. HA presentation on CD44 of endothelial cells serves as a substrate for T cells to interact and, in conjunction with selectin interactions, mediates rolling of the T cell, thus slowing the cell and allowing for further adhesion of LFA-1 to ICAM-1. The T cell is then able to traverse the endothelial barrier in a process called diapedesis where it migrates through tissue to participate in the inflammatory response [64,65,66]. Adapted from “Leukocyte Migration at Sites of Infection”, by BioRender.com (2021). Retrieved from app.biorender.com/biorender-templates.