Table 1.

Updates on clinical trials of metformin and OvCa.

Disease Condition	Treatment	Summary	Trial Phase Status	Clinical Trial Number
Advanced stage OvCa	Metformin with carboplatin/paclitaxel	mTOR pathway inhibition, p53-induced apoptosis.	Phase1	NCT02312661
Advanced stage OvCa	Paclitaxel, carboplatin, and oral metformin	Increased synergy without compromising patient tolerability.	Phase 2	NCT02437812
Advanced epithelial OvCa in Stages IIIa–-IV	Metformin, acetylsalicylic acid, olaparib, and letrozole	Women with advanced (stage IIIa-IV) OvCa of the histologic subtype high-grade serous carcinoma (HGSOC) are going through a diagnostic laparoscopy. They will receive treatment with a study agent for 10–14 days before surgery. The study is randomized and unblinded.	Early Phase 1	NCT03378297
Complex endometrial hyperplasia with atypia grade 1 endometrial endometrioid adenocarcinoma	Levonorgestrel and metformin	Metformin is an effective treatment for early-stage endometrial cancer and endometrial hyperplasia with atypia.	Phase 2	NCT01686126
Ovarian, fallopian tube, and primary peritoneal cancer	Metformin	To determine if metformin administered in combination with chemotherapy to women with advanced ovarian, primary peritoneal, or fallopian tube cancer will improve recurrence-free survival at 18 months compared to controls.	Phase 2	NCT01579812
Cancer	Metformin, atorvastatin, doxycycline, and mebendazole	To determine the effectiveness of a regimen of selected metabolic treatments for patients with cancer in a real-world setting and to conduct exploratory analysis on the relationship between the degree of response and changes in biochemical markers (such as glucose and lipid levels).	Phase 3	NCT02201381