Table 2.
Ongoing clinical trials evaluating combination of CDK inhibitors and RT in different diseases.
| NCT Number | Study Type | Cancer Type | Trial Title | Sponsors and Collaborators |
|---|---|---|---|---|
| NCT02290145 | Interventional, Phase II | Squamous cell carcinoma of mouth |
CCND1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage | •Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China |
| NCT04585724 | Interventional, Phase I | Metastatic breast carcinoma |
Stereotactic Radiosurgery with Abemaciclib, Ribociclib, or Palbociclib in Treating Patients with Hormone Receptor Positive Breast Cancer with Brain Metastases | •Grady Health System, Atlanta, GA, United States |
| NCT03024489 | Interventional, Phase II | Head and neck cancer | Palbociclib with Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma | •Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand |
| NCT02607124 | Interventional, Phase II | High grade glioma | A Phase I/II Study of Ribociclib, a CDK4 and CDK6 Inhibitor, Following Radiation Therapy | •Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States |
| NCT04298983 | Interventional, Phase II | Prostate cancer | Abemaciclib in Combination with Androgen Deprivation Therapy for Locally Advanced Prostate Cancer | University of Alabama at Birmingham |
| NCT04923542 | Interventional, Phase II | Brain metastases from breast cancer | Stereotactic Radiation and Abemaciclib in the Management of ESR1+/HER2- Breast Cancer Brain Metastases | •H. Lee Moffitt Cancer Centerand Research Institute |
| NCT04220892 | Interventional, Phase I | High grade glioma | Pilot Study of Pembrolizumab Combined with Pemetrexed or Abemaciclib for High Grade Glioma | •Jose Carrillo •Eli Lilly and Company •John Wayne Cancer Institute |
| NCT03355794 | Interventional, Phase I | Cerebral glioma | A Study of Ribociclib and Everolimus Following Radiation Therapy in Children with Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) | Children’s Hospital Medical Center, Cincinnati, OH, United States •Novartis |
| NCT03691493 | Interventional, Phase II | Bone metastases from breast cancer | Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients with Bone Metastasis | •Emory University •Pfizer |
| NCT03870919 | Interventional, Phase I | Breast cancer stage IV | Locoregional Treatment and Palbociclib in de Novo, Treatment Naive, Stage IV ESR1+, HER2- Breast Cancer Patients | •UNICANCER •Pfizer |
| NCT03024489 | Interventional, Phase II | Head and neck cancer | Palbociclib with Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma | •Mahidol University |
| NCT04563507 | Interventional, Phase II | Breast cancer stage IV | Combined Immunotherapies in Metastatic ESR1+ Breast Cancer | •Weill Medical College of Cornell University |
| NCT03389477 | Interventional, Phase II | Head and neck cancer | Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients with p16INK4a Negative, HPV- Unrelated Head and Neck Squamous Cell Carcinoma | •Washington University School of Medicine •Pfizer |
| NCT04605562 | Interventional, Phase II | Nasopharyngeal carcinoma | Umbrella Biomarker-Guided Therapy in NPC | •Sun Yat-sen University |
| NCT02624973 | Interventional, Phase II | Breast cancer | PErsonalized TREatment of High-risk MAmmary Cancer—the PETREMAC Trial | •Haukeland University Hospital •Helse Vest •Pfizer •AstraZeneca |