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. 2021 Aug 4;22(16):8380. doi: 10.3390/ijms22168380

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Aged Opa1^+/− mice had increased levels of 3-Nitrotyrosine in the GCL. (A) Representative images from 3-nitrotyrosine (3-NT) immunostaining. The top row shows 3-NT staining in green, the middle row is a nuclear stain, and the bottom row shows the overlay of the two stains. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. Scale bar represents 20 µm. (B) Quantification of fluorescence showed significantly increased levels of 3-NT in Opa1^+/− mice compared to WT controls. WT Sham (n = 3), WT Light (n = 4), Opa1^+/− Sham (n = 4), Opa1^+/− Light (n = 2). * p < 0.05, two-way ANOVA.