Figure 4.

SH003 and docetaxel inhibited tumor growth in H460 xenograft mouse model in vivo. H460 cells (1 × 10⁷ cells/mice) were inoculated subcutaneously and the growth of the implanted tumor in different groups of mice was calculated longitudinally. (A) Measurement of xenograft tumors volume. (B) Orange and blue arrows indicate treatment with SH003 and docetaxel, respectively. At the beginning, the tumors in the four groups grew similarly in all aspects for 1 week, whereas tumor growth was retarded in the SH003- and DTX-treated group until 2 weeks. On day 21, the mean tumor volume in the combination group was smaller than that in the control xenograft group. Statistical significance was determined using the one-way ANOVA with Tukey’s test comparing control *** p < 0.001. (C) Tumor weights. Statistical significance was determined using the one-way ANOVA with Tukey’s test comparing control * p < 0.05 and *** p < 0.001 versus control. (D) The body weight was measured once every 3 days. The measured body weights between individual groups were similar.