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EPH/ephrin family role in solid tumors of the brain, salivary glands, thyroid, lung, breast, and skin. Red-colored EPHs/ephrins enhance tumorigenesis, while green-colored ones suppress it. EPHB2 in breast cancer can play both roles, depending on its location: cytoplasmic EPHB2 expression promotes carcinogenesis, while membranous EPHB2 expression favors tumor-suppression. Created with BioRender.com (accessed on 2 August 2021).
