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. 2021 Aug 5;22(16):8417. doi: 10.3390/ijms22168417

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Long-term potentiation (LTP) was attenuated in the CA1 hippocampal area after administration of ceftriaxone (CTX). (a) Representative examples of field excitatory postsynaptic potential (fEPSP) before induction (1) and 60 min after theta-burst stimulation (TBS) or high-frequency stimulation (HFS) (2). (b) Diagram showing changes in the value of the normalized slope of fEPSP in the control (CTRL) and CTX-treated (CTX) animals after TBS or HFS. Black arrow indicates the moment of LTP induction (TBS or HFS). (c) Diagram illustrating the differences in LTP between the control and CTX-treated (CTX) animals according to the type of induction protocol. All the data are presented as mean ± standard error of the mean. * p < 0.05: a significant difference versus the control group (’Tukey’s post hoc test).