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A scheme illustrating the attenuation of the glutamate spillover with GLT1 expression increase. In control, glutamate released from neighboring terminals might pool and spill over to adjoining synapses and extrasynaptic receptors (a), while GLT1 overexpression attenuates the glutamate spillover (b). For simplicity, only NMDA receptors are shown. SC-Schaffer collateral, GLT1-glutamate transporter 1.
