2′OMe |
2′-O-methyl ribose sugar modification |
3′ss |
3′ splice site |
3UP8 |
8mer ASO that partially targets ISS-N1 |
5′ss |
5′ splice site |
A3S |
Alternative 3′ splice site usage |
A5S |
Alternative 5′ splice site usage |
Anti-N1 |
20mer ASO targeting ISS-N1 |
ASO |
antisense oligonucleotide |
EIN |
Increased exon inclusion |
ESK |
Increased exon skipping |
F14 |
14mer ASO that targets ISS-N1 |
F18 |
18mer ASO that targets ISS-N1 |
HiA |
High concentration (100 nM) of Anti-N1 |
IRM |
Improved intron removal |
IRT |
Increased intron retention |
ISO |
ISS-N1 targeting splice switching ASO |
ISS-N1 |
Intronic splicing silencer N1 |
L2FC |
log(2) fold change |
LoA |
Low concentration (5 nM) of Anti-N1 |
MOE |
2′-O-methoxyethyl ribose sugar modification |
MXE |
Mutually exclusive exons and/or mixed events |