Table 4.
Cellular Line | Dose and Time of Exposure | Objective | Results | Reference |
---|---|---|---|---|
SH-SY5Y | CLO: 1–100 μM for 24 h | Assess whether CLO could affect the structure or function of the human nervous system |
|
[200] |
SK-N-SH | IMI, ACE, TMX: 10–2000 mg/L for 24 h | Study the toxicity of NNs alone or in combination |
|
[204] |
SH-SY5Y | IMI, ACE, CLO, THI, TMX: 0.05–4 mM for 24 and 48 h | Investigate the possible effects of common NN insecticides on cytotoxicity and DNA damage |
|
[205] |
Abbreviations. IMI: imidacloprid; ACE: acetamiprid; TMX: thiametoxam; NN: neonicotinoid; CLO: clothianidin; nAChR: nicotinic acetylcholine receptor; THI: thiacloprid; TMX: thiametoxam; ERK: extracellular signal-regulated kinase.