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. 2021 Aug 6;22(16):8482. doi: 10.3390/ijms22168482

Figure 2.

Figure 2

PCA and GSEA analysis of in vitro cardiac models. GSEA analysis performed using gene loadings from PC1 and PC2. Associated GO terms depict redundant GO terms filtered out through REViGO. (A) PCA of 2D hiPSC-CMs, 3D hiPSC-CMs and hCOs. (B) 10 significantly enriched GO terms along PC1(+)(top) and PC1(–)(bottom): PC1(+) depicted pathways enriched in hCOs; PC1(–) depicts pathways co-enriched in 2D hiPSC-CMs and 3D hiPSC-CMs. (C) 10 significantly enriched GO terms along PC2(+)(top) and PC2(–)(bottom): PC2(+) represents pathways enriched in 2D hiPSC-CMs; PC2(–) represents pathways enriched in 3D hiPSC-CMs.