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. 2021 Aug 6;22(16):8482. doi: 10.3390/ijms22168482

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PCA and k-means cluster analysis of a cardiomyocyte specific gene set. (A) PCA of cardiomyocyte gene expression in 2D hiPSC-CMs, 3D hiPSC-CMs, hCOs, fetal ventricles and adult ventricles. (B) Heatmap of cardiomyocyte gene expression of 2D hiPSC-CMs, 3D hiPSC-CMs, hCOs, fetal ventricles and adult ventricles. Genes were categorized by reported biological processes characteristic of cardiomyocytes. (C) Comparison of in vitro hiPSC-CM platforms. Genes were categorized by known cellular functions characteristic of cardiomyocytes.