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. 2021 Aug 9;22(16):8547. doi: 10.3390/ijms22168547

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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AVR-48 protects against BPD-PH. (A) The RV/LV ratio and Fulton’s Index (RV/LV+IVS) is improved after AVR-48 treatment in the BPD group. (B) Representative Western blot showing an increased expression of Vegf in the BPD+AVR-48 treated group as compared to BPD group. (C) eNOS, BmpRII and VegfD, which are increased in BPD, are noticeably decreased after treatment with AVR-48. Vinculin is the loading control. As the same samples were used for Figure 7A,B and Figure 8B,C, the same vinculin has been shown for both images as the loading control. n = 4–5. BPD-PH: bronchopulmonary dysplasia-associated pulmonary hypertension; RV: right ventricle; LV: left ventricle; IVS: interventricular septum; RA: room air; BPD: bronchopulmonary dysplasia; Vegf: vascular endothelial growth factor; eNOS: endothelial nitric oxide synthase; BmpRII: bone morphogenetic protein receptor 2. * p < 0.05; ** p < 0.01; *** p < 0.001.