Table 2.
Protein regulation in the temporal quadrant 2 weeks after pONT compared to contralateral control (p < 0.05 and fold-change log2 > 0.43 (upregulation) or ≤ −0.43 (downregulation)). R = right; L = left; FC = fold change.
| Uniprot | Protein Name | FC L/R | LogFC | p-Value |
|---|---|---|---|---|
| Upregulation | ||||
| M0R9G2 (P06238) | Alpha-2-macroglobulin | 3.02 | 1.59 | 0.00 |
| P11883 | Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase family 3 member A1) (HTC-ALDH) (Tumor-associated aldehyde dehydrogenase) | 2.61 | 1.39 | 0.01 |
| G3V836 | Clusterin | 2.33 | 1.22 | 0.00 |
| P01048 | T-kininogen 1 (Alpha-1-MAP) (Major acute phase protein) (T-kininogen I) (Thiostatin) (cleaved into: T-kininogen 1 heavy chain (T-kininogen I heavy chain); T-kinin; T-kininogen 1 light chain (T-kininogen I light chain)) | 2.33 | 1.21 | 0.04 |
| P52631 | Signal transducer and activator of transcription 3 | 2.22 | 1.15 | 0.02 |
| A0A0G2QC06 | Serotransferrin | 2.16 | 1.11 | 0.02 |
| F1LM19 | Alpha-2-HS-glycoprotein | 2.03 | 1.02 | 0.03 |
| D3ZVR7 | Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) | 2.03 | 1.02 | 0.04 |
| D3ZS58 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2 | 1.98 | 0.99 | 0.04 |
| P02767 | Transthyretin (Prealbumin) (TBPA) | 1.92 | 0.94 | 0.03 |
| G3V7F1 | G protein beta subunit-like, isoform CRA_a (Target of rapamycin complex subunit LST8) | 1.90 | 0.92 | 0.03 |
| G3V8Q4 | Retinol binding protein 3, interstitial (Retinol-binding protein 3) | 1.83 | 0.87 | 0.02 |
| P47819 | Glial fibrillary acidic protein (GFAP) | 1.79 | 0.84 | 0.01 |
| A0A0G2JUT0 | Heat shock-related 70 kDa protein 2 | 1.65 | 0.73 | 0.03 |
| A0A0G2K151 | Apolipoprotein E | 1.63 | 0.70 | 0.04 |
| Q63041 | Alpha-1-macroglobulin (Alpha-1-M) (Alpha-1-macroglobulin 165 kDa subunit) (cleaved into: Alpha-1-macroglobulin 45 kDa subunit) | 1.62 | 0.70 | 0.04 |
| Q9QYU4 | Ketimine reductase mu-crystallin (EC 1.5.1.25) (CDK108) (NADP-regulated thyroid-hormone-binding protein) | 1.62 | 0.70 | 0.01 |
| Q07936 | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | 1.61 | 0.68 | 0.00 |
| Q5XFX0 | Transgelin-2 | 1.58 | 0.66 | 0.01 |
| G3V7K3 | Ceruloplasmin (Ceruloplasmin, isoform CRA_a) | 1.56 | 0.64 | 0.02 |
| Q4V8F6 | Pcbp2 protein (Poly(rC)-binding protein 2) | 1.51 | 0.59 | 0.03 |
| Q5RJR2 | Twinfilin-1 | 1.50 | 0.59 | 0.03 |
| A0A0G2KB52 | Microtubule-associated protein 7 | 1.50 | 0.56 | 0.04 |
| M0R9D5 | “Obsolete” | 1.47 | 0.55 | 0.03 |
| D3ZTB5 | S100 calcium-binding protein A13 | 1.47 | 0.55 | 0.05 |
| G3V818 | Alpha-parvin (Parvin, alpha, isoform CRA_a) | 1.45 | 0.54 | 0.03 |
| Q5XI38 | Lymphocyte cytosolic protein 1 | 1.44 | 0.53 | 0.01 |
| H1UBN0 | Copine-7 (Copine VII) | 1.43 | 0.52 | 0.01 |
| P62870 | Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) | 1.39 | 0.48 | 0.01 |
| Q63798 | Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) | 1.38 | 0.47 | 0.01 |
| P97608 | 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) | 1.38 | 0.47 | 0.03 |
| F1M9N7 | Arf-GAP domain and FG repeat-containing protein 1 | 1.37 | 0.46 | 0.05 |
| D4A7F2 | Myc-binding protein (RCG31143) | 1.37 | 0.45 | 0.03 |
| P52759 | 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Liver perchloric acid-soluble protein) (L-PSP) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (EC 3.1.-.-) (UK114 antigen homolog) (rp14.5) | 1.37 | 0.45 | 0.03 |
| F2Z3T8 | Guanine nucleotide-binding protein subunit gamma | 1.36 | 0.45 | 0.04 |
| M0R567 | Interferon regulatory factor 2-binding protein-like | 1.35 | 0.44 | 0.00 |
| A1L1L5 | Ccnk protein (Cyclin K) | 1.35 | 0.43 | 0.00 |
| Downregulation | ||||
| D4ADS8 (Rab4a) | Ras-related protein Rab-4A | 0.74 | −0.43 | 0.01 |
| G3V6W2 | Prolactin regulatory element-binding protein (RCG62389, isoform CRA_a) | 0.74 | −0.44 | 0.04 |
| D4ADS4 | Microsomal glutathione S-transferase 3 (RCG46430) | 0.72 | −0.45 | 0.01 |
| P11275 | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | 0.72 | −0.46 | 0.02 |
| Q6XDA0 | Spectrin beta chain | 0.72 | −0.48 | 0.00 |
| Q6IMZ3 | Annexin | 0.70 | −0.48 | 0.01 |
| D3ZPC4 | Neural cell adhesion molecule L1 | 0.70 | −0.51 | 0.02 |
| Q32Q88 | F-box protein 22 (RCG58340, isoform CRA_b) | 0.70 | −0.52 | 0.00 |
| Q4V7F2 | Cysteine-rich with EGF-like domain protein 1 | 0.70 | −0.52 | 0.04 |
| O09032 | ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) | 0.69 | −0.53 | 0.00 |
| P97846 | Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190) | 0.69 | −0.53 | 0.02 |
| Q6PW52 | GABA-A gamma2 long isoform (Gamma-aminobutyric acid A receptor, gamma 2) (Gamma-aminobutyric acid receptor subunit gamma-2) | 0.68 | −0.55 | 0.01 |
| O35760 | Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1) | 0.68 | −0.56 | 0.01 |
| G3V679 | Transferrin receptor protein 1 (Transferrin receptor, isoform CRA_a) | 0.68 | −0.56 | 0.02 |
| P12839 | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | 0.66 | −0.60 | 0.04 |
| P62762 | Visinin-like protein 1 (VILIP) (21 kDa CABP) (Neural visinin-like protein 1) (NVL-1) (NVP-1) | 0.66 | −0.60 | 0.00 |
| G3V7U2 | Microtubule-associated protein 1 A, isoform CRA_c (Microtubule-associated protein 1A) | 0.65 | −0.62 | 0.00 |
| P63041 | Complexin-1 (Complexin I) (CPX I) (Synaphin-2) | 0.62 | −0.69 | 0.00 |
| F1LRZ7 | Neurofilament heavy polypeptide | 0.61 | −0.71 | 0.01 |
| P01830 | Thy-1 membrane glycoprotein (Thy-1 antigen) (CD antigen CD90) | 0.57 | −0.81 | 0.00 |
| G3V774 | F-box only protein 2 (F-box protein 2) | 0.56 | −0.83 | 0.02 |
| P19527 | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) | 0.54 | −0.88 | 0.01 |
| A0A0G2JZL9 | Endothelial cell-selective adhesion molecule | 0.53 | −0.90 | 0.03 |
| A0A0G2K0T6 | Gamma-synuclein | 0.38 | −1.41 | 0.00 |
| F1LUD3 | AHNAK nucleoprotein 2 | 0.30 | −1.74 | 0.01 |