Table 1.

Synthesis of 2-(adamantan-1-ylamino)thiazol-4(5H)-one.

No.	R1	R2	Procedure	Isolated Yield [%]	M.p. (°C)
3a	H	H	A	64.1	271–273
3b	H	CH3	A	75.8	265–267
3c	H	C2H5	A	66.1	257–259
3d	H	C3H7	A	60.1	247–249
3e	H	CH(CH3)2	B	18.7	239–241
3f	CH3	CH3	B	15.8	208–210
3g	H	C6H5	A	66.2	252–254
3h	H	C6H5p-Br	A	25.4	320 (dec.)
3i	-(CH2)5-		C	14.6	268–270
3j	-(CH2)3-		C	28.3	265–266

A-MeOH, MeONa; reflux, B: CHCl₃, RT; C: EtOH, DIPEA, reflux.