Table 3.

Physicochemical properties of the obtained series of 2-(adamantylamino)thiazol-4(5H)-one derivatives.

Compound	miLogP	tPSA [A2]	Molecular Weight [g/mol]	nON	nOHNH	Number Rotatable Bonds	PAINS *
3a	2.64	41.46	250.37	3	1	2	0
3b	3.00	41.46	264.39	3	1	2	0
3c	3.51	41.46	278.42	3	1	3	0
3d	4.07	41.46	292.45	3	1	4	0
3e	3.75	41.46	292.45	3	1	3	0
3f	3.45	41.46	278.42	3	1	2	0
3g	4.22	41.46	326.46	3	1	3	0
3h	5.03	41.46	405.36	3	1	3	0
3i	4.62	41.46	318.49	3	1	2	0
3j	3.37	41.46	290.43	3	1	2	0

nOHNH—hydrogen bond donor; nON—hydrogen bond acceptor, tPSA—topological polar surface area, * Alerts of PAINS were determined according [47,48,49].