Table 2.

Macromolecule characterization reported for pEVs in therapeutical approaches.

Kind of Proteins Commonly Reported	pEV Markers	References
EV membrane markers	CD9	[25,30,33,34,39,44,46,47,48]
	CD61	[33,36]
	CD63	[25,26,30,33,34,39,44,47,48,66]
	D81	[30,33,34,39,44,47]
Platelet source markers	CD31	[34]
	CD41	[33,34,37,38,42,44,48,67,68,69]
	CD42	[40]
EV cytosolic markers	ALIX	[46,48]
	HSP90	[33]
	HPS101	[47]
	TSG101	[44]
Non-EVs structures	APOA1	[46,48]
	APOB100	[46,48]
	Calnexin	[44]