Table 1.
Early (1, 8 DPL peak) and late (45 DPL peak) profiles deregulated pathways in the Spinal Cord segment rostral to the lesion.
| NAME | ID | SIZE | ES | NES | NOM.p.val | FDR.q.val | FWER.p.val |
|---|---|---|---|---|---|---|---|
| 1 DPL | |||||||
| REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING | R-RNO-6785807 | 8 | 0.922751 | 2.960325 | 0 | 0.001343 ** | 0.001 |
| REACTOME_SIGNALING_BY_INTERLEUKINS | R-RNO-449147 | 15 | 0.59045 | 2.48295 | 0 | 0.02287 * | 0.036 |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | M5890 | 14 | 0.591473 | 2.428519 | 0 | 0.020713 * | 0.048 |
| GOBP_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY | GO:0010466 | 6 | 0.83201 | 2.357697 | 0 | 0.026939 * | 0.082 |
| GOBP_OSTEOCLAST_DIFFERENTIATION | GO:0030316 | 6 | 0.807556 | 2.354578 | 0 | 0.021834 * | 0.082 |
| REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | R-RNO-381340 | 6 | 0.807932 | 2.300164 | 0 | 0.027823 * | 0.125 |
| GOBP_OSSIFICATION | GO:0001503 | 9 | 0.624718 | 2.155755 | 0.003165 | 0.069799 | 0.32 |
| GOBP_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY | GO:2000117 | 5 | 0.793688 | 2.100962 | 0.00274 | 0.09092 | 0.439 |
| GOBP_MYELOID_LEUKOCYTE_DIFFERENTIATION | GO:0002573 | 11 | 0.594451 | 2.088907 | 0.003676 | 0.086556 | 0.455 |
| GOBP_MYELOID_CELL_DIFFERENTIATION | GO:0030099 | 13 | 0.502879 | 2.049668 | 0 | 0.097413 | 0.537 |
| GOBP_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY | GO:0007215 | 17 | −0.64627 | −2.23902 | 0 | 0.031969 * | 0.036 |
| 8 DPL | |||||||
| REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING | R-RNO-6785807 | 8 | 0.784993 | 2.51836 | 0 | 0.021501 * | 0.015 |
| 45 DPL | |||||||
| GOBP_CELL_CELL_SIGNALING | GO:0007267 | 56 | 0.573257 | 2.007903 | 0 | 0.06429 | 0.117 |
| GOBP_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING | GO:0099177 | 40 | 0.549315 | 1.942583 | 0 | 0.081764 | 0.277 |
| GOBP_POSITIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS | GO:0045935 | 28 | −0.43293 | −1.97778 | 0 | 0.082897 | 0.595 |
| REACTOME_NGF_STIMULATED_TRANSCRIPTION | R-RNO-9031628 | 9 | −0.66178 | −2.01156 | 0.014235 | 0.069736 | 0.493 |
| GOBP_IMMUNE_SYSTEM_DEVELOPMENT | GO:0002520 | 17 | −0.50455 | −2.01332 | 0 | 0.077424 | 0.489 |
| HALLMARK_APOPTOSIS | M5902 | 6 | −0.79285 | −2.06413 | 0.003185 | 0.057833 | 0.346 |
| GOBP_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS | GO:0009891 | 27 | −0.47244 | −2.09493 | 0 | 0.05279 | 0.282 |
| GOBP_MONONUCLEAR_CELL_DIFFERENTIATION | GO:1903131 | 7 | −0.80153 | −2.10801 | 0.003155 | 0.057605 | 0.261 |
| GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II | GO:0045944 | 24 | −0.51624 | −2.26319 | 0 | 0.013703 * | 0.056 |
| GOBP_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II | GO:1902895 | 7 | −0.80546 | −2.26659 | 0 | 0.017004 * | 0.052 |
| GOBP_PRI_MIRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II | GO:0061614 | 7 | −0.80546 | −2.27329 | 0 | 0.022732 * | 0.046 |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | M5890 | 14 | −0.76035 | −2.75168 | 0 | 0 ** | 0 |
* FDR ≤ 0.05; ** FDR ≤ 0.005.