Table 2.
Early (1, 8 DPL peak) profiles deregulated pathways in the Spinal Cord segment caudal to the lesion.
| NAME | ID | SIZE | ES | NES | NOM.p.val | FDR.q.val | FWER.p.val |
|---|---|---|---|---|---|---|---|
| 1 DPL | |||||||
| REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING | R-RNO-6785807 | 8 | 0.9 | 2.823968 | 0 | 0 ** | 0 |
| REACTOME_SIGNALING_BY_INTERLEUKINS | R-RNO-449147 | 15 | 0.571289 | 2.286192 | 0.003788 | 0.09028 | 0.118 |
| GOBP_CYTOKINE_MEDIATED_SIGNALING_PATHWAY | GO:0019221 | 16 | 0.55529 | 2.273639 | 0 | 0.066719 | 0.129 |
| GOBP_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY | GO:0010466 | 6 | 0.816037 | 2.221286 | 0 | 0.0732 | 0.185 |
| REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS | R-RNO-442755 | 16 | −0.61111 | −1.96957 | 0 | 0.06652 | 0.439 |
| REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | R-RNO-399719 | 11 | −0.69351 | −2.03043 | 0 | 0.03897 * | 0.245 |
| REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | R-RNO-418594 | 18 | −0.61807 | −2.10975 | 0 | 0.01606 * | 0.092 |
| GOBP_CELL_CELL_SIGNALING | GO:0007267 | 56 | −0.56237 | −2.17293 | 0 | 0.00946 * | 0.044 |
| REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION | R-RNO-112314 | 22 | −0.63534 | −2.23874 | 0 | 0.006321 * | 0.023 |
| REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES | R-RNO-112315 | 23 | −0.65278 | −2.33446 | 0 | 0.002479 ** | 0.006 |
| REACTOME_NEURONAL_SYSTEM | R-RNO-112316 | 26 | −0.6346 | −2.35683 | 0 | 0.003253 ** | 0.004 |
| 8 DPL | |||||||
| REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING | R-RNO-6785807 | 8 | 0.85 | 2.650963 | 0 | 0.004133 ** | 0.003 |
| GOBP_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY | GO:0010466 | 6 | 0.829268 | 2.291362 | 0 | 0.058247 | 0.082 |
| REACTOME_SIGNALING_BY_GPCR | R-RNO-372790 | 22 | −0.5614 | −1.85086 | 0.003501 | 0.098777 | 0.748 |
| REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS | R-RNO-442755 | 16 | −0.60603 | −1.90244 | 0.002331 | 0.075281 | 0.55 |
| GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY | GO:0048167 | 21 | −0.58122 | −1.92569 | 0.001145 | 0.063086 | 0.455 |
| REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | R-RNO-418594 | 18 | −0.61145 | −1.95418 | 0 | 0.051105 | 0.361 |
| GOBP_CELL_CELL_SIGNALING | GO:0007267 | 56 | −0.54694 | −1.97041 | 0 | 0.047453 * | 0.304 |
| GOBP_SENSORY_PERCEPTION | GO:0007600 | 9 | −0.74845 | −1.97867 | 0.001295 | 0.050751 | 0.278 |
| GOBP_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING | GO:0099177 | 40 | −0.55088 | −2.01597 | 0 | 0.036091 * | 0.183 |
| GOBP_RESPONSE_TO_ETHANOL | GO:0045471 | 5 | −0.92069 | −2.05396 | 0.001368 | 0.029496 * | 0.128 |
| REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION | R-RNO-112314 | 22 | −0.6351 | −2.10719 | 0 | 0.019659 * | 0.066 |
| REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES | R-RNO-112315 | 23 | −0.6471 | −2.22689 | 0 | 0.004021 ** | 0.009 |
| REACTOME_NEURONAL_SYSTEM | R-RNO-112316 | 26 | −0.6586 | −2.30701 | 0 | 0.003537 ** | 0.004 |
* FDR ≤ 0.05; ** FDR ≤ 0.005.