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Adverse event summary table
| Adverse Events | n (%) |
|---|---|
| Total events | 134 |
| Grade 3 or higher* | 21 (15·7%) |
| Fever | 5 (3·7%) |
| Headache | 3 (2·2%) |
| Hematological events | 6 (4·5%) |
| Increased WBC | 2 (1·5%) |
| Neutropenia | 2 (1·5%) |
| Thrombocytopenia | 2 (1·5%) |
| Thrombocytosis | 1 (0·7%) |
| Anemia | 1 (0·5%) |
| Pruritis | 1 (0·5%) |
| Neurological worsening due to PML | 25 (18·7%) |
| Worsening of underlying disease | 10 (7·5%) |
| Intercurrent illness | 21 (15·7%) |
no AE grade 3 or higher deemed treatment-related
