Table 1.
Reports of primary pancreatic follicular lymphoma
| Author | Year | Ref | n | Age | Sex | Location | Size (cm) | Symptoms | Stage (Lugano) | Diagnostic method | EUS-FNA passes | Failed methods | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prayer | 1992 | [5] | 4a | N/A | N/A | N/A | 6–12 | N/A | N/A | Surgery or biopsy | – | – | N/A | N/A |
| Behrns | 1994 | [6] | 3b | N/A | N/A | N/A | 8–12 | N/A | IE | Surgery | – | – | Biliary bypass, gastroenterostomy | Survived |
| N/A | N/A | N/A | 8–12 | N/A | IE | Surgical biopsy | – | – | Radiation | Survived | ||||
| N/A | N/A | N/A | 8–12 | N/A | IIE | Surgery | – | – | Gastroenterostomy, chemoradiotherapy | Survived | ||||
| Bouvet | 1998 | [7] | 1 | 72 | M | Head | 5 | Fatigue | IE | Surgical biopsy | – | – | Chemotherapy (CHOP-bleomycin), radiation | CR |
| Koniaris | 2000 | [8] | 1 | 63 | M | Head | NA | None | IIE | Surgery (PD) | – | – | Surgery (PD) | CR |
| Nishimura | 2001 | [9] | 2 | 63 | M | Head | NA | Fatigue | IE | Surgery | – | – | Surgery, chemotherapy | CR |
| 82 | M | Head | NA | Pain | IE | Autopsy | – | – | None | Died of disease | ||||
| Volmar | 2004 | [10] | 3 | 78 | M | Head | 5.4 | N/A | N/A | EUS-FNA | 8 |
CT-FNA US-FNA |
N/A | N/A |
| 51 | M | Head | 14 | N/A | N/A | EUS-FNA, CT-FNA | 1 | – | N/A | N/A | ||||
| 57 | F | Head | 4.3 | N/A | N/A | CT-FNA | 6 | EUS-FNA | N/A | N/A | ||||
| Grimison | 2006 | [11] | 1 | 56 | M | Head | 5 | Dyspepsia, weight loss | IIE | Laparotomy | – | – | Radiation, chemotherapy (CVP, rituximab) | CR |
| Sata | 2007 | [12] | 1 | 58 | M | Head | 8 | Pain | IIE | Laparotomy | – | – | Surgery, radiation | CR |
| Malin | 2010 | [2] | 2c | N/A | N/A | N/A | N/A | N/A | N/A | N/A | – | – |
Radiation (1) Chemotherapy (1) |
N/A |
| Ravi | 2010 | [13] | 1 | 73 | F | Head | 6 | Jaundice | IIE | CT-FNA | – | EUS-FNA (pancreas and lymph nodes) | Chemotherapy (R-CHOP) | N/A |
| Alexander | 2011 | [14] | 1 | 61 | M | Head | 5 | Jaundice, fatigue, weight loss | IIE | Surgery (PD) | – | EUS-FNA (not attempted due to intervening vessels) | Surgery, chemotherapy (R-CHOP 6 cycles) | CR |
| Shirai | 2015 | [15] | 1 | 71 | F | Body | 5 | Pain | IIE | Surgery (DP) | – | EUS-FNA (not attempted due to hypervascularity) | Surgery, chemotherapy | N/A |
| Boninsegnad | 2018 | [16] | 5 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | – | N/A | N/A | N/A |
| Sallapan | 2018 | [17] | 1 | 75 | M | Head | 5 | Jaundice | IIE | Surgery (PD) | – | – | N/A | N/A |
| Facchinellid | 2020 | [4] | 4 | N/A | N/A | N/A | N/A | N/A | N/A | Surgery (1) | – | – | Surgery (1), Chemotherapy (BR, 2), None (1) | N/A |
| Our cases | 2021 | 2 | 67 | M | Head (multiple) | 4 | None | IIE | EUS-FNA | 2 | – | Chemotherapy (GB, G maintenance) | CR | |
| 70 | M | Body, tail (multiple) | 1.5 | None | IIIE | Laparoscopy | 4, 4, 8 | EUS-FNA | Chemotherapy (GB, G maintenance) | CR |
CR complete response, CT-FNA computed tomography-guided fine-needle spiration, DP distal pancreatectomy, EUS-FNA Endoscopic ultrasound-guided fine-needle aspiration, G obinutuzumab, GB obinutuzumab/bendamustine, PD pancreaticoduodenectomy, US-FNA ultrasound-guided fine-needle aspiration
aThree cases of centrocytic/centroblastic lymphoma and one case of centrocytic lymphoma based on the Kiel classification
bTwo cases of follicular mixed cell lymphoma and one case of follicular large cell lymphoma
cOne other case included in the report (excluded from this analysis) was diffuse large B-cell lymphoma with a focus of follicular lymphoma, grade 3
dPossible overlap due to overlap in reporting institutions