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. 2021 Aug 11;22(16):8648. doi: 10.3390/ijms22168648

Figure 2.

Figure 2

Analysis of the levels of Hb, metHb, and total and free heme in IVH-III (G3) and IVH-IV (G4) CSF samples at different time intervals after the disease onset. A time-dependent alteration of Hb (A), metHb (B), and total and free heme (C,D) was uncovered in post-IVH CSF samples, which was more pronounced in Grade-IV IVH patients (G4, red) compared to the Grade-III group (G3, light red). Dots represent single values. Mean ± SEM are depicted. Dotted lines depict the mean value of the particular parameter measured in preterm non-IVH control samples [23]. Mean total heme was as low as 0.8 μmol/L and free heme was practically undetectable in the control samples, and this is why the dotted lines cannot be recognized in parts C and D. To compare the data of the two groups, the Mann–Whitney U test or unpaired t-test was applied. Abbreviations: CSF, cerebrospinal fluid; G3, Grade-III IVH; G4, Grade-IV IVH; Hb, hemoglobin; IVH, intraventricular hemorrhage; and metHb, methemoglobin.