Table 1.
Name | Sequence 1 | Application | Ref |
---|---|---|---|
Anticancer Applications—Diagnostic | |||
VEGF-P3(CYC) | I76TMQ79CG92IHQGQHPKIRMI80CE93MSF96 * | Inhibition angiogenesis | [38,39] |
D(LPR) | D(Leu-Pro-Arg) | Inhibition retinal angiogenesis; Diagnostic | [41,42,43] |
SP5 | PRPSPKMGVSVS * | Drug delivery | [44,45] |
uPAR88–92 | SRSRY * | Maintaining chemotactic activity and triggers directed cell migration and angiogenesis | [46,47] |
RI-3 | Ac-D(Tyr- Arg-Aib-Arg)- NH2 | Prevent extracellular invasion by tumor cells | [48] |
D(RGD) | D(Asp-Gly-Arg) | Diagnostic | [49,50,51] |
VS | SWFSRHRYSPFAVS * | Glioblastoma multiforme (GBM) | [52,53] |
VAP | SNTRVAP * | Gliomas, glioma stem cells, vasculogenic mimicry and neovasculature | [54] |
WSW | SYPGWSW * | Glioma cells and tumor neovasculature | [55] |
BK | RPPGFSPFR * | Glioma cells | [56] |
FP21 | YTRDLVYGDPARPGIQGTGTF * | Ovarian cancer | [57,58,59] |
T7 | HAIYPRH * | Drug delivery | [60] |
Applications in Immunology | |||
TG19320 | (rty)4K2KG | IgG binding | [61,62] |
VSVp | RGYVYQGL * | antigen surface of hepatitis B virus | [63] |
OVAp | SIINFEKL * | antigen surface of hepatitis B virus | [63] |
PS1 | HQLDPAFGANSTNPD * | antigen surface of hepatitis B virus | [63] |
HAI | HAIYPRH * | Crossing BBB | [64] |
THR | THRPPMWSPVWP * | Crossing BBB | [64] |
InsB:9–23 | HLVEALYLVCGERGG * | Analogue of diabetogenic islet peptide—prevents T-cell activation in humanized model mice | [65,66] |
Application in Neurodegenerative Diseases | |||
Amytrap | WKGEWTGR * | Blocking the oligomerization and aggregation of Aβ1–42 | [67,68,69,70,71] |
IAPP11–20 | RLANFLVHSS * | Strong inhibitory effects on amylin aggregation in T2DM | [72] |
β-syn36–45 | GVLYVGSKT * | Reduction of amyloid fibril and oligomer formation | [73] |
Application in Antimicrobial Antibiotics | |||
RI1018 | rrwirvavilrv | Preventing formation of Biofilm | [74] |
RI-JK6 | rivwvrirrwqv | Preventing formation of Biofilm | [74] |
RI-73 | lwGvwrrvidwlr | Damaging the bacterial membrane | [75] |
BMAP-28 | GGLRSLGRKILRAWKKYGPIIVPIIRIG * | Broad antimicrobial activities | [76] |
1 The sequences reported are those of the parent peptides * (L-residues), unless otherwise indicated, like reporting D residues as lower-case letters or adding a “D” before the sequence.