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. 2021 Aug 12;22(16):8677. doi: 10.3390/ijms22168677

Table 1.

Names, peptide sequences reported in the review and their applications.

Name Sequence 1 Application Ref
Anticancer Applications—Diagnostic
VEGF-P3(CYC) I76TMQ79CG92IHQGQHPKIRMI80CE93MSF96 * Inhibition angiogenesis [38,39]
D(LPR) D(Leu-Pro-Arg) Inhibition retinal angiogenesis; Diagnostic [41,42,43]
SP5 PRPSPKMGVSVS * Drug delivery [44,45]
uPAR88–92 SRSRY * Maintaining chemotactic activity and triggers directed cell migration and angiogenesis [46,47]
RI-3 Ac-D(Tyr- Arg-Aib-Arg)- NH2 Prevent extracellular invasion by tumor cells [48]
D(RGD) D(Asp-Gly-Arg) Diagnostic [49,50,51]
VS SWFSRHRYSPFAVS * Glioblastoma multiforme (GBM) [52,53]
VAP SNTRVAP * Gliomas, glioma stem cells, vasculogenic mimicry and neovasculature [54]
WSW SYPGWSW * Glioma cells and tumor neovasculature [55]
BK RPPGFSPFR * Glioma cells [56]
FP21 YTRDLVYGDPARPGIQGTGTF * Ovarian cancer [57,58,59]
T7 HAIYPRH * Drug delivery [60]
Applications in Immunology
TG19320 (rty)4K2KG IgG binding [61,62]
VSVp RGYVYQGL * antigen surface of hepatitis B virus [63]
OVAp SIINFEKL * antigen surface of hepatitis B virus [63]
PS1 HQLDPAFGANSTNPD * antigen surface of hepatitis B virus [63]
HAI HAIYPRH * Crossing BBB [64]
THR THRPPMWSPVWP * Crossing BBB [64]
InsB:9–23 HLVEALYLVCGERGG * Analogue of diabetogenic islet peptide—prevents T-cell activation in humanized model mice [65,66]
Application in Neurodegenerative Diseases
Amytrap WKGEWTGR * Blocking the oligomerization and aggregation of Aβ1–42 [67,68,69,70,71]
IAPP11–20 RLANFLVHSS * Strong inhibitory effects on amylin aggregation in T2DM [72]
β-syn36–45 GVLYVGSKT * Reduction of amyloid fibril and oligomer formation [73]
Application in Antimicrobial Antibiotics
RI1018 rrwirvavilrv Preventing formation of Biofilm [74]
RI-JK6 rivwvrirrwqv Preventing formation of Biofilm [74]
RI-73 lwGvwrrvidwlr Damaging the bacterial membrane [75]
BMAP-28 GGLRSLGRKILRAWKKYGPIIVPIIRIG * Broad antimicrobial activities [76]

1 The sequences reported are those of the parent peptides * (L-residues), unless otherwise indicated, like reporting D residues as lower-case letters or adding a “D” before the sequence.