Table 2.

The effects of KL001 on Drosophila melanogaster lifespan.

Treatment	Sex	N	Mortality Percentiles (Days)
			25%	50%	75%	90%
H2O (negative control)	♂	181	48	58	62	68
0.1% DMSO (control)	♂	152	54	58	58	60
0.1% DMSO, 1 µM KL001	♂	152	53	57	60	63 +
0.1% DMSO, 5 µM KL001	♂	151	52	59 *#@	63	66 +
0.1% DMSO, 10 µM KL001	♂	155	54	54	58	65 +
0.1% DMSO, 50 µM KL001	♂	148	54	58	61	64 +
H2O (negative control)	♀	134	58	72	75	79
0.1% DMSO (control)	♀	152	30	33	54	64
0.1% DMSO, 1 µM KL001	♀	149	29	39 +	57	64
0.1% DMSO, 5 µM KL001	♀	151	28	45 +	56	63
0.1% DMSO, 10 µM KL001	♀	152	26	37	51	58
0.1% DMSO, 50 µM KL001	♀	153	30	44 +	52	61

*—p < 0.001 according to the Gehan-Breslow-Wilcoxon test; +—p < 0.05 (0.0413) according to the Wang-Allison test, #—p = 0.0268, comparison with negative control (water-treated group), Gehan-Breslow-Wilcoxon test; @—p < 0.0001, Wang Allison test compared with water-treated cohort; the underlined values were significantly statistically different from negative water-treated control, the 4–7th columns had p < 0.0001, Wang-Allison test, the 5th column was tested with Gehan-Breslow-Wilcoxon test and all values had p < 0.0001); the p-values are mentioned with Bonferroni correction. The most prominent geroprotective effects on lifespan were observed in male flies. N—Number of flies.