Figure 1.

Burn study design schematic and treatment protocol. (A) Animals received Clostridium collagenase treatment daily. Tissues were collected at 0, 1, 2, 4 and 7 days post-burn from different burn wound interspaces from comb burns on two pigs and processed for histology. Black bars indicate location for vehicle hydrogel treatment and blue bars indicate collagenase hydrogel treatment location on porcine drawing. (B) Representative H&E and MT section stains for day 0 tissues collected. Areas of burned ‘B’ and unburned ‘UB’ tissue are indicated to demonstrate the focus area at the burn edge.