Figure 2.

Representative images of the immunohistochemical staining for SDC1, -2, -3, and -4, and SDCBP in non-neoplastic tissues (Pb-Cre4-negative—wild type) and tumoral prostatic lobes from Pb-Cre4/Pten^f/f genetic engineered mouse model. (A–C) SDC1. (D–F) SDC2. (G–I) SDC3. (J–L) SDC4. (M–O) SDCBP. Prostatic intraepithelial neoplasia (PIN). Advanced tumors (AdTumor). In the non-neoplastic prostatic lobes, positive immunostaining was observed in the interstitial connective tissue (solid arrows), blood vessels (BV), and smooth muscle cells (open arrows). A weak or negative reaction was observed in the secretory epithelial cells for all SDCs and SDCBP. At the PIN and advanced stages of the tumor (asterisks), strong immunostaining for SDC1 in the tumoral epithelial cells, weak immunostaining for SDC4 and SDCBP, and negative immunostaining for SDC2 and SDC3 were observed. Scale bars: 100 μm.