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. 2021 Aug 12;22(16):8669. doi: 10.3390/ijms22168669

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative images of the immunohistochemical staining for SDC1, -2, -3, and -4, and SDCBP in tumors found in the different prostatic lobes from the Pb-Cre4/Trp53f/f-;Rb1f/f genetically engineered mouse model. (A,B) SDC1; (C,D) SDC2; (E,F) SDC3; (G,H) SDC4; (I,J) SDCBP. Prostatic intraepithelial neoplasia (PIN) and advanced tumors (AdTumor). In the PIN areas and advanced tumors, positive immunostaining was observed for SDC3 (E) and SDCBP (I) (solid arrows). Blood vessels (BV); smooth muscle cells (open arrow). Scale bars: 100 μm.