Table 1.
Alteration observed in the molecular species of the 20 most discriminating phospholipid species (according to one-way ANOVA and Fisher’s LSD post hoc tests) in the plasma of control rats (Ctr) and rats irradiated with UVA (increasing doses from 0.5 to 5 J/cm2 for 4 weeks) or rats irradiated with UVB (increasing doses from 0.02 to 2 J/cm2 for 4 weeks). These animals were not treated (Ctr, UVA, and UVB) or were treated topically with CBD (CBD, UVA+CBD, and UVB+CBD) (2.5 g CBD in 100 g petrolatum);↑ upregulation; ↓ downregulation.
| Phospholipid Specie | Log2 (Fold-Change) | ||||||
|---|---|---|---|---|---|---|---|
| CBD vs. Ctr | UVA vs. Ctr | UVA+CBD vs. Ctr | UVA+CBD vs. UVA | UVB vs. Ctr | UVB+CBD vs. Ctr | UVB+CBD vs. UVB | |
| LPE(16:0) | - | 1.33 ↑ | - | 1.15 ↓ | 4.47 ↑ | - | 4.15 ↓ |
| LPE(18:2) | - | 1.06 ↑ | - | 1.13 ↓ | 4.07 ↑ | - | 4.08 ↓ |
| LPE(18:0) | - | 1.69 ↑ | - | 1.60 ↓ | 4.20 ↑ | - | 4.12 ↓ |
| LPE(20:4) | - | 1.26 ↑ | - | 1.01 ↓ | 3.77 ↑ | - | 3.62 ↓ |
| LPE(22:6) | - | 1.87 ↑ | - | 1.59 ↓ | 4.58 ↑ | - | 4.55 ↓ |
| PC(38:5) | - | 2.11 ↑ | - | 1.59 ↓ | 2.02 ↑ | - | 1.11 ↓ |
| PC(38:6) | - | 1.67 ↑ | - | 1.29 ↓ | 1.77 ↑ | - | 1.04 ↓ |
| PC(38:3) | - | 2.09 ↑ | - | 1.98 ↓ | 2.01 ↑ | - | 1.67 ↓ |
| LPC(16:1) | - | 2.64 ↑ | - | 2.52 ↓ | 2.92 ↑ | - | 3.20 ↓ |
| LPC(22:6) | - | 1.99 ↑ | - | 2.29 ↓ | 4.58 ↑ | - | 2.38 ↓ |
| LPC(20:3) | - | 2.42 ↑ | - | 2.71 ↓ | 2.53 ↑ | - | 2.28 ↓ |
| LPC(18:1) | - | 2.47 ↑ | - | 2.57 ↓ | 2.62 ↑ | - | 2.22 ↓ |
| LPC(16:0) | - | 2.60 ↑ | - | 2.33 ↓ | 3.22 ↑ | - | 2.21 ↓ |
| PEo(40:7) | 2.11 ↑ | - | 1.55 ↑ | 1.93 ↑ | - | 3.50 ↑ | 4.12 ↑ |
| PEo(38:4) | 2.60 ↑ | - | 1.96 ↑ | 2.20 ↑ | - | 3.76 ↑ | 4.69 ↑ |
| PEo(40:4) | 1.83 ↑ | - | 2.40 ↑ | 2.83 ↑ | 1.47 ↓ | 3.55 ↑ | 4.59 ↑ |
| PEo(40:6) | 1.78 ↑ | - | 1.87 ↑ | 2.32 ↑ | - | 3.09 ↑ | 3.91 ↑ |
| SM(d38:1) | - | 1.63 ↓ | 1.89 ↓ | - | 2.01 ↓ | 2.61 ↓ | - |
| SM(d42:2) | - | 1.53 ↓ | 1.53 ↓ | - | 2.29 ↓ | 2.58 ↓ | - |
| SM(d40:1) | - | 1.45 ↓ | 1.43 ↓ | - | 1.99 ↓ | 2.26 ↓ | - |