Table 2.
The alteration observed in the molecular species of the 20 most discriminating ceramide species (according to the one-way ANOVA and Tukey’s post hoc tests) in plasma of control rats (Ctr) and the rats irradiated with UVA (increasing doses from 0.5 to 5 J/cm2 for 4 weeks) or rats irradiated with UVB (increasing doses from 0.02 to 2 J/cm2 for 4 weeks). These animals were not treated (Ctr, UVA, and UVB) or were treated topically with CBD (CBD, UVA+CBD, and UVB+CBD) (2.5 g CBD in 100 g petrolatum);↑ upregulation; ↓ downregulation. (non-hydroxy fatty acid [N], dihydrosphingosine [DS], and sphingosine [S]).
| CER Class | Ceramide Specie | Log2 (Fold-Change) | ||||||
|---|---|---|---|---|---|---|---|---|
| CBD vs. Ctr | UVA vs. Ctr | UVA+CBD vs. Ctr | UVA+CBD vs. UVA | UVB vs.Ctr | UVB+CBD vs. Ctr | UVB+CBD vs. UVB | ||
| CER[NS] | Cer(d18:1/23:0) | 1.27 ↑ | 3.10 ↑ | 3.21 ↑ | - | 3.36 ↑ | 1.96 ↑ | 1.11 ↑ |
| CER[NS] | Cer(d18:2/23:0) | 2.32 ↑ | 3.96 ↑ | 4.05 ↑ | - | 5.12 ↑ | 5.66 ↑ | - |
| CER[NS] | Cer(d15:2/22:0) | 1.34 ↑ | 3.48 ↑ | 2.83 ↑ | - | 4.50 ↑ | 4.08 ↑ | - |
| CER[NS] | Cer(d16:1/17:0) | 2.99 ↑ | 5.26 ↑ | 4.82 ↑ | - | 6.08 ↑ | 5.48 ↑ | - |
| CER[NS] | Cer(d18:1/18:1) | 1.27 ↑ | 3.75 ↑ | 3.28 ↑ | - | 4.26 ↑ | 4.25 ↑ | - |
| CER[NS] | Cer(d18:2/20:1) | - | 1.09 ↑ | 2.11 ↑ | 1.02 ↑ | 2.33 ↑ | 2.75 ↑ | - |
| CER[NS] | Cer(d18:1/25:0) | - | 7.33 ↑ | 6.41 ↑ | - | 7.96 ↑ | 8.01 ↑ | - |
| CER[NS] | Cer(d18:1/24:1) | - | 2.17 ↑ | 2.08 ↑ | - | 2.77 ↑ | 2.52 ↑ | - |
| CER[NS] | Cer(d18:1/17:0) | - | 2.51 ↑ | 2.20 ↑ | - | 3.06 ↑ | 3.05 ↑ | - |
| CER[NS] | Cer(d18:1/19:0) | - | 2.26 ↑ | 2.22 ↑ | - | 2.83 ↑ | 2.81 ↑ | - |
| CER[NS] | Cer(d18:1/18:0) | - | 2.99 ↑ | 2.97 ↑ | - | 2.87 ↑ | 2.41 ↑ | - |
| CER[NS] | Cer(d18:1/26:0) | - | 2.08 ↑ | 2.32 ↑ | - | 2.38 ↑ | 2.66 ↑ | - |
| CER[NS] | Cer(d18:1/20:0) | - | 1.76 ↑ | 1.42 ↑ | - | 2.04 ↑ | 2.31 ↑ | - |
| CER[NS] | Cer(d16:1/22:0) | - | 1.77 ↑ | 1.41 ↑ | - | 2.05 ↑ | 2.32 ↑ | - |
| CER[NS] | Cer(d18:1/24:0) | - | 1.46 ↑ | 1.32 ↑ | - | 2.07 ↑ | 2.10 ↑ | - |
| CER[NS] | Cer(d18:2/22:0) | - | 0.97 ↑ | - | - | 1.83 ↑ | 1.85 ↑ | - |
| CER[NDS] | Cer(d18:0/18:0) | 1.96 ↑ | 3.45 ↑ | 4.01 ↑ | - | 4.11 ↑ | 4.46 ↑ | - |
| CER[NDS] | Cer(d18:0/17:0) | - | 2.62 ↑ | 2.06 ↑ | - | 2.92 ↑ | 3.05 ↑ | - |
| CER[NDS] | Cer(d18:0/16:0) | - | 2.72 ↑ | 2.21 ↑ | - | 2.38 ↑ | 2.01 ↑ | - |
| CER[NDS] | Cer(d18:0/26:0) | - | 2.15 ↑ | 2.05 ↑ | - | 2.07 ↑ | 2.24 ↑ | - |