Table 3.

Genetic testing performed in each patient.

Patient	Genetic Variant Identified	Genetic Screening Performed
1	BRCA1 (c.212+3A>G, p.?)	Analysis of known family variant
2	BRCA2 (c.6644_6647del, p.Ty2215Serfs*13)	Analysis of known family variant
3	CHEK2 (c.1100del, p.Thr367Metfs*15)	Analysis of known family variant
4	BRCA2 (c.516+1G>A, p.?)	Analysis of known family variant
5	BRCA1 (c.5186T>A, p.Leu1729Gln)	ATM, BRIP1, CDH1, CHEK2, MLH1, MSH2, MSH6, NBN (only c.657_661del), PALB2, PTEN, RAD51C, RAD51D, TP53 Additional testing: NGS sequencing of tumor tissue
6	BRCA2 (c.4936_4939del, p.Glu1646Glnfs*23)	Analysis of known family variant
7	BRCA1 (c.212+3A>G, p.?)	Analysis of known family variant
8	No class 4 or 5 variant found	HaloPlex panel
9	No class 4 or 5 variant found	HaloPlex panel
10	No class 4 or 5 variant found	HaloPlex panel
11	No class 4 or 5 variant found	HaloPlex panel
12	No class 4 or 5 variant found	HaloPlex panel
13	No class 4 or 5 variant found	HaloPlex panel
14	No class 4 or 5 variant found	HaloPlex panel
15	No class 4 or 5 variant found	HaloPlex panel
16	No class 4 or 5 variant found	BRCA hereditary cancer MASTR plus kit
17	No class 4 or 5 variant found	BRCA hereditary cancer MASTR plus kit
18	No class 4 or 5 variant found	BRCA hereditary cancer MASTR plus kit
19	No class 4 or 5 variant found	FamCanc + Precision 2 trial (BMSO)
20	No class 4 or 5 variant found	HaloPlex panel

Abbreviations: ATM = Ataxia Telangiectasia Mutated; BRCA1 = BRCA1 DNA Repair Associated; BRCA2 = BRCA2 DNA Repair Associated; BRIP1 = BRCA1 interacting protein C-terminal helicase 1; CDH1 = cadherin 1; CHEK2 = checkpoint kinase 2; MLH1 = MutL Homolog 1; MSH2 = MutS Homolog 2; MSH6 = MutS Homolog 6; NBN = Nibrin; PALB2 = Partner And Localizer Of BRCA2; PTEN = Phosphatase And Tensin Homolog; RAD51C = RAD51 paralog C; RAD51D = RAD51 paralog D; TP53 = Tumor Protein P53; NGS = next generation sequencing.