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irAE characteristics described by site/organ per each age group.
| Type of irAE | All Toxicity n = 113 (%) | <70 n = 53 (%) | ≥70 n = 60 (%) | p (<70 vs. ≥70) |
|---|---|---|---|---|
| Pneumonitis | 14 (9.6) | 6 (11.3) | 8 (13.3) | p = 0.758 |
| Colitis | 19 (13) | 8 (15.1) | 11 (18.3) | p = 0.769 |
| Hepatitis | 6 (4.1) | 4 (7.5) | 2 (3.3) | p = 0.157 |
| Skin reactions | 27 (18.5) | 6 (11.3) | 21 (35.0) | p = 0.047 |
| Rheumatological | 13 (8.9) | 8 (15.1) | 5 (8.3) | p = 0.081 |
| Endocrine related | 34 (23.3) | 21 (39.7) | 13 (21.7) | p = 0.002 |
