Aβ |
amyloid beta |
AD |
Alzheimer´s disease |
APP |
transgenic mice containing the human mutated APPswe |
APP/D |
APP mice with diffuse Aβ deposits and ≤10 Aβ plaques/mm2
|
APP/P |
APP mice with ≥ 10 Aβ plaques/mm2
|
ASC |
apoptosis-associated speck-like protein containing a caspase recruitment domain |
CARD |
caspase recruitment domain |
DG |
dentate gyrus |
GFAP |
glial fibrillary acidic protein |
HP |
hippocampus |
Iba1 |
ionized calcium-binding adapter protein 1 |
IF |
inflammasome |
IL |
interleukin |
LM |
stratum lacunosum-molecularis of hippocampus |
NeuN |
neuronal nuclei |
NLR |
NOD-like receptors |
NLRP1 |
NLR family PYD-containing 1 |
NLRP3 |
NLR family PYD-containing 3 |
NLRC4 |
NLR family CARD-containing 4 |
NOD |
nucleotide binding and oligomerization domain |
PRR |
pattern recognition receptors |
PYD |
pyrin domain |
RLM |
strata radiatum, lacunosum-molecularis of hippocampus and stratum molecularis of dentate gyrus |
ROS |
radical oxygen species |
TGF-β |
transforming growth factor-β |
TNF-α |
tumor necrosis factor-α |
WT |
wild type |