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. 2021 Aug 11;22(16):8642. doi: 10.3390/ijms22168642

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The JNK pathway mediates visfatin-induced MMP-2 expression and cell migration. (A–F) Cells were pretreated with a JNK inhibitor (SP600125) or transfected with a JNK siRNA, then stimulated with visfatin. Cell migration and levels of MMP-2 expression were examined by Transwell, wound healing, and qPCR. (G) Cells were incubated with visfatin for the indicated time intervals; JNK phosphorylation was examined by Western blot. Quantitative results are expressed as the mean ± SD. All experiments were repeated 3 to 5 times. * p < 0.05 compared with the UT group; # p < 0.05 compared with the visfatin-treated group. UT, untreated control.