Figure 4.
The impact of topically applied epinephrine to skin upon the survival of mice after IV inoculation of L1210 cells. Twenty four hr after IV L1210 inoculation (104 cells), backs of mice were clipped with a clippers, 45 μl of the indicated epinephrine formulations in an ethanol:water (70:30) vehicle was applied to an ~1.5 cm2 area of clipped skin, and 20 min later, mice were weighed and received a single IP injection of cyclophosphamide (CP, 90 μg/gm bw). Mice were observed every 12 hrs to record deaths per half day. There were 8 mice per treatment group. A dashed line showing the 50% survival point, where survival times in each group were statistically compared, is indicated.